Cármen Vieira

  • Neurodegenerative diseases
  • Machado-Joseph disease
  • therapy
  • serotonin
  • neuronal circuits

Cármen Vieira holds a Master’s degree in Neurobiology and a Bachelor’s degree in Biochemistry, from the University of Porto. Cármen is currently the recipient of a scholarship granted by the National Ataxia Foundation, USA, to develop novel therapies for Spinocerebellar Ataxias, namely by studying intermittent fasting dietary regimens, under the direct guidance of Dr. Andreia Teixeira-Castro, within the Translational Neurogenetics team at ICVS. She is particularly interested in the molecular mechanisms and neuronal circuitry (dys)function underlying neurological diseases, and how modulation of those circuits may positively impact these disorders. She is also actively involved in science outreach activities: she co-organized the International Rare Disease Day (2021) initiative at ICVS, diffused throughout the social media.

Scientific Highlights

Jalles, A.*, Vieira, C.*, Pereira-Sousa, J., Vilasboas-Campos, D., Mota, A. F., Vasconcelos, S., Ferreira-Lomba, B., Costa, M. D., Da Silva, J. D., Maciel, P., & Teixeira-Castro, A. (2022). Aripiprazole Offsets Mutant ATXN3-Induced Motor Dysfunction by Targeting Dopamine D2 and Serotonin 1A and 2A Receptors in C. elegans. Biomedicines, 10(2), 370. https://doi.org/10.3390/biomedicines10020370

De-Castro, A. R. G.*, Rodrigues, D. R. M.*, De-Castro, M. J. G., Vieira, N., Vieira, C., Carvalho, A. X., Gassmann, R., Abreu, C. M. C., & Dantas, T. J. (2022). WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing. The Journal of cell biology, 221(1), e202010178. https://doi.org/10.1083/jcb.202010178

Monti, G., Kjolby, M., Jensen, A. M. G., Allen, M., Reiche, J., Møller, P. L., Comaposada-Baró, R., Zolkowski, B. E., Vieira, C., Jørgensen, M. M., Holm, I. E., Valdmanis, P. N., Wellner, N., Vægter, C. B., Lincoln, S. J., Nykjær, A., Ertekin-Taner, N., Young, J. E., Nyegaard, M., & Andersen, O. M. (2021). Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer’s disease. Acta neuropathologica communications, 9(1), 43. https://doi.org/10.1186/s40478-021-01140-7


Serotonin signaling and proteostasis

This project addresses an unmet medical need- the lack of effective treatment for any of the aging-associated neurodegenerative diseases. Due to the worldwide aging of the population, by 2050 it is expected that over 135 million people…

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