Scientific Highlights

Articles

Monteiro-Fernandes, D., Charles, I., Guerreiro, S., Cunha-Garcia, D., Pereira-Sousa, J., Oliveira, S., Teixeira-Castro, A., Varney, M. A., Kleven, M. S., Newman-Tancredi, A., P Sheikh Abdala, A., Duarte-Silva, S., & Maciel, P. (2025). Rescue of respiratory and cognitive impairments in Rett Syndrome mice using NLX-101, a selective 5-HT1A receptor biased agonist. Biomedicine & pharmacotherapy, 186, 117989. https://doi.org/10.1016/j.biopha.2025.117989

Duarte-Silva, S.*, Da Silva, J. D.*, Monteiro-Fernandes, D.*, Costa, M. D., Neves-Carvalho, A., Raposo, M., Soares-Cunha, C., Correia, J. S., Nogueira-Goncalves, G., Fernandes, H. S., Oliveira, S., Ferreira-Fernandes, A. R., Rodrigues, F., Pereira-Sousa, J., Vilasboas-Campos, D., Guerreiro, S., Campos, J., Meireles-Costa, L., Rodrigues, C. M. P., Cabantous, S., Sousa, S. F., Lima, M., Teixeira-Castro, A., & Maciel, P. (2024). Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of spinocerebellar ataxia type 3. The Journal of Clinical Investigation, 134(5), e162246. https://doi.org/10.1172/JCI162246

Cunha-Garcia, D., Monteiro-Fernandes, D., Correia, J. S., Neves-Carvalho, A., Vilaça-Ferreira, A. C., Guerra-Gomes, S., Viana, J. F., Oliveira, J. F., Teixeira-Castro, A., Maciel, P., & Duarte-Silva, S. (2023). Genetic Ablation of Inositol 1,4,5-Trisphosphate Receptor Type 2 (IP3R2) Fails to Modify Disease Progression in a Mouse Model of Spinocerebellar Ataxia Type 3. International Journal of Molecular Sciences, 24(13), 10606. https://doi.org/10.3390/ijms241310606

Campos, A. B.*, Duarte-Silva, S.*, Fernandes, B., das Neves, S. P., Marques, F., Teixeira-Castro, A., Neves-Carvalho, A., Monteiro-Fernandes, D., Portugal, C. C., Socodato, R., Summavielle, T., Ambrósio, A. F., Relvas, J. B., & Maciel, P. (2022). Profiling Microglia in a Mouse Model of Machado-Joseph Disease. Biomedicines, 10(2), 237. https://doi.org/10.3390/biomedicines10020237

Mendes-Pinheiro, B., Soares-Cunha, C., Marote, A., Loureiro-Campos, E., Campos, J., Barata-Antunes, S., Monteiro-Fernandes, D., Santos, D., Duarte-Silva, S., Pinto, L., & José Salgado, A. (2021). Unilateral Intrastriatal 6-Hydroxydopamine Lesion in Mice: A Closer Look into Non-Motor Phenotype and Glial Response. International Journal of molecular sciences, 22(21), 11530. https://doi.org/10.3390/ijms222111530

Monteiro-Fernandes, D., Sousa, N., Almeida, O. F. X., & Sotiropoulos, I. (2021). Sex Hormone Depletion Augments Glucocorticoid Induction of Tau Hyperphosphorylation in Male Rat Brain. Neuroscience, 454, 140–150. https://doi.org/10.1016/j.neuroscience.2020.05.049

Monteiro-Fernandes, D., Silva, J. M., Soares-Cunha, C., Dalla, C., Kokras, N., Arnaud, F., Billiras, R., Zhuravleva, V., Waites, C., Bretin, S., Sousa, N., & Sotiropoulos, I. (2021). Allosteric modulation of AMPA receptors counteracts Tau-related excitotoxic synaptic signaling and memory deficits in stress- and Aβ-evoked hippocampal pathology. Molecular Psychiatry, 26(10), 5899–5911. https://doi.org/10.1038/s41380-020-0794-5