
Treatment of chronic bacterial infections: Bacteriophages as a potential treatment option
Life-threatening human infectious diseases caused by bacterial pathogens are now re-emerging, in part due to increased resistance to antibiotics.
Henrique graduated with a degree in Biochemistry in 2013 and completed his MSc in Health Sciences in 2015 at the University of Minho. During his MSc, he worked under the supervision of Dr. Margarida Saraiva and Dr. Egídio Torrado at the Life and Health Sciences Research Institute (ICVS), to uncover the impact of a Mycobacterium tuberculosis virulence factor using a model of infection. From 2015 to 2016, Henrique continued his research at ICVS under Professor Margarida Correia-Neves, studying the dynamics of tuberculosis transmission in the city of Porto. He later worked for the Faculty of Medicine of University of Lisbon (FMUL) as a technician carrying out complementary diagnostic tests in the context of primary immunodeficiencies. In 2017, he joined the LisbonBioMed PhD program at the FMUL and became part of the Biology of Parasitism group at the Institute of Molecular Medicine (IMM), where he worked under the supervision of Professor Luísa Figueiredo. His research focused on the mechanisms behind Trypanosoma brucei colonization of host adipose tissue. Henrique completed his PhD in December 2022 and continued his work at IMM until late 2023. In November 2024, he returned to ICVS to join the research group of Professor Jorge Pedrosa, where he aims to explore novel therapeutic approaches for the treatment of Buruli ulcer, specifically using bacteriophages against its causative agent.
Henrique graduated with a degree in Biochemistry in 2013 and completed his MSc in Health Sciences in 2015 at the University of Minho. During his MSc, he worked under the supervision of Dr. Margarida Saraiva and Dr. Egídio Torrado at the Life and Health Sciences Research Institute (ICVS), to uncover the impact of a Mycobacterium tuberculosis virulence factor using a model of infection. From 2015 to 2016, Henrique continued his research at ICVS under Professor Margarida Correia-Neves, studying the dynamics of tuberculosis transmission in the city of Porto. He later worked for the Faculty of Medicine of University of Lisbon (FMUL) as a technician carrying out complementary diagnostic tests in the context of primary immunodeficiencies. In 2017, he joined the LisbonBioMed PhD program at the FMUL and became part of the Biology of Parasitism group at the Institute of Molecular Medicine (IMM), where he worked under the supervision of Professor Luísa Figueiredo. His research focused on the mechanisms behind Trypanosoma brucei colonization of host adipose tissue. Henrique completed his PhD in December 2022 and continued his work at IMM until late 2023. In November 2024, he returned to ICVS to join the research group of Professor Jorge Pedrosa, where he aims to explore novel therapeutic approaches for the treatment of Buruli ulcer, specifically using bacteriophages against its causative agent.
[1] Machado, Henrique; Hofer, Peter; Zechner, Rudolf; Smith, Terry K.; Figueiredo, Luísa M. “Adipocyte lipolysis
protects mice against Trypanosoma brucei infection”. Nature Microbiology 8 11 (2023): 2020-2032.
[2] Machado, Henrique; Bizarra-Rebelo, Tiago; Costa-Sequeira, Mariana; Trindade,Sandra; Carvalho, Tânia; Rijo-Ferreira, Filipa; Rentroia-Pacheco, Barbara; Serre,Karine; Figueiredo, Luisa M.. “Trypanosoma brucei triggers a broad immuneresponse in the adipose tissue”. PLOS Pathogens 17 9 (2021): e1009933.
[3]Machado, Henrique; Figueiredo, Luisa M.. “Polyreactive Antibodies Bridge Immunity Particles to Pathogen”. Trends in Parasitology 36 10 (2020): 804-806.
[4]Bhatt, Kiranmai*; Machado, Henrique*; Osório, Nuno S.; Sousa, Jeremy; Cardoso,Filipa; Magalhães, Carlos; Chen, Bing; et al. “A Nonribosomal Peptide SynthaseGene Driving Virulence in Mycobacterium tuberculosis”. mSphere 3 5 (2018).
Life-threatening human infectious diseases caused by bacterial pathogens are now re-emerging, in part due to increased resistance to antibiotics.
Phone: +351 253 604 967
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Email: icvs.sec@med.uminho.pt
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
Copyright ©2022 ICVS. All Rights Reserved
Copyright ©2022 ICVS. All Rights Reserved
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
Copyright ©2022 ICVS. All Rights Reserved
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal