Imane Hurel

  • reward; aversion
  • associative learning
  • nucleus accumbens
  • medium-spiny neurons
I am a postdoctoral researcher at ICVS, University of Minho. I obtained a PhD in Neuroscience from the University of Bordeaux (France) in 2023, where I investigated the role of the endocannabinoid system in motivated behaviors. During my doctoral training under the supervision of Dr. Francis Chaouloff in Dr. Giovanni Marsicano’s laboratory, I implemented a wide range of behavioral paradigms based on operant conditioning to dissect the neurobiological mechanisms underlying the dysregulated balance between food intake and physical activity observed in eating disorders.
By combining behavioral neuroeconomics, pharmacological and viral approaches, my research revealed that cannabinoid receptors located on GABAergic interneurons sex-dependently gate long-term cost-benefit decision-making between feeding and exercise. This work provided me with a strong foundation in experimental design and circuit –level approaches, resulting in six peer-reviewed publications including three as co-first author, and the presentation of my work at major international conferences (FENS, SFN).
Following my PhD and first postdoctoral experience, I strategically broadened my research focus and methodological expertise. Thus, in 2025, I joined the laboratory of Dr. Ana João Rodrigues, recognized for its strong technical expertise in the field of reward and aversion, to further develop my independent research profile. This transition enabled me to acquire new methodologies, including single-cell calcium imaging, optogenetics and advanced computational analyses enabling a deeper understanding of neural population dynamics that support adaptive and maladaptive behavior.

Imane Hurel

  • reward; aversion
  • associative learning
  • nucleus accumbens
  • medium-spiny neurons
I am a postdoctoral researcher at ICVS, University of Minho. I obtained a PhD in Neuroscience from the University of Bordeaux (France) in 2023, where I investigated the role of the endocannabinoid system in motivated behaviors. During my doctoral training under the supervision of Dr. Francis Chaouloff in Dr. Giovanni Marsicano’s laboratory, I implemented a wide range of behavioral paradigms based on operant conditioning to dissect the neurobiological mechanisms underlying the dysregulated balance between food intake and physical activity observed in eating disorders.
By combining behavioral neuroeconomics, pharmacological and viral approaches, my research revealed that cannabinoid receptors located on GABAergic interneurons sex-dependently gate long-term cost-benefit decision-making between feeding and exercise. This work provided me with a strong foundation in experimental design and circuit –level approaches, resulting in six peer-reviewed publications including three as co-first author, and the presentation of my work at major international conferences (FENS, SFN).
Following my PhD and first postdoctoral experience, I strategically broadened my research focus and methodological expertise. Thus, in 2025, I joined the laboratory of Dr. Ana João Rodrigues, recognized for its strong technical expertise in the field of reward and aversion, to further develop my independent research profile. This transition enabled me to acquire new methodologies, including single-cell calcium imaging, optogenetics and advanced computational analyses enabling a deeper understanding of neural population dynamics that support adaptive and maladaptive behavior.

Scientific Highlights

1. Hurel, I. *, Muguruza, C.*, Redon, B., Marsicano, G., and Chaouloff, F. (2021). Cannabis and exercise: Effects of Δ9-tetrahydrocannabinol on preference and motivation for wheel-running in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry 105, 110117.
2. Medrano, M.*, Hurel, I.*, Mesguich, E., Redon, B., Stevens, C., Georges, F., Melis, M., Marsicano, G., and Chaouloff, F. (2021). Exercise craving potentiates excitatory inputs to ventral tegmental area dopaminergic neurons. Addiction Biology 26.
3. Redon, B., Hurel, I., Marsicano, G., and Chaouloff, F. (2019). An Operant Conditioning Task to Assess the Choice between Wheel Running and Palatable Food in Mice. BIO-PROTOCOL 9.
4. Hurel, I.*, Redon, B.*, Scocard, A., Malezieux, M., Marsicano, G., and Chaouloff, F. (2019). Beyond the Activity-Based Anorexia Model: Reinforcing Values of Exercise and Feeding Examined in Stressed Adolescent Male and Female Mice. Front. Pharmacol. 10, 587.
5. Muguruza, C., Redon, B., Fois, G.R., Hurel, I., Scocard, A., Nguyen, C., Stevens, C., Soria-Gomez, E., Varilh, M., Cannich, A., et al. (2019). The motivation for exercise over palatable food is dictated by cannabinoid type-1 receptors. JCI Insight 4, e126190.

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