Scientific Highlights
Selected Publications:
“Distinct disease-modifying therapies are associated with different blood immune cell profiles in people with relapsing-remitting multiple sclerosis”
J. Canto-Gomes, D. Boleixa, C. Teixeira, A. Martins da Silva, I. González-Suárez, J. J. Cerqueira, M. Correia-Neves and C. Nobrega
International Immunopharmacology. (2024). 131:111826
DOI: 10.1016/j.intimp.2024.111826.
“People with Primary Progressive Multiple Sclerosis have a lower number of central memory T cells and HLA-DR+ Tregs”
J. Canto-Gomes, S. da Silva-Ferreira, C. S. Silva, D. Boleixa, A. Martins da Silva, I. González-Suárez, J. J. Cerqueira, M. Correia-Neves and C. Nobrega
Cells (2023). 12(3):439
DOI: 10.3390/cells12030439
“HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation”
H. Yang, H. Sun, S. Brackenridge, X. Zhuang, P. A. C. Wing, M. Quastel, L. Walters, L. Garner, B. Wang, X. Yao, S. Ling Felce, Y. Peng, S. Moore, B. W. A. Peeters, M. Rei, J. Canto-Gomes, A. Tomas, A. Davidson, M. G. Semple, L. C. W. Turtle, P. J. M. Openshaw, J. K. Baillie, A. J. Mentzer, P. Klenerman, ISARIC4C Investigators, P. Borrow, T. Dong, J. A. McKeating, G. M. Gillespie, A. J. McMichael
Science Immunology (2023). 8(84).eabl8881
DOI: 10.1126/sciimmunol.abl8881.
“Low memory T cells blood counts and high naïve regulatory T cells percentage at relapsing remitting multiple sclerosis diagnosis”
J. Canto-Gomes, C. S. Silva, R. Rb-Silva, D. Boleixa, A. Martins Da Silva, R. Cheynier, P. Soares Costa, I. González- Suárez, M. Correia-Neves, J. J. Cerqueira and C. Nobrega
Front. Immunol. (2022). 13: 901165
DOI: 10.3389/fimmu.2022.901165
“Increased Gal-3BP plasma levels in hospitalized patients infected with SARS-CoV-2”
V. Gallo, ISERC-Team, R. Gentile, G. Antonini, S. Iacobelli
Clin. Exp. Med. (2022). 23:151
DOI: 10.1007/s10238-021-00788-8.
“Performance assessment of 11 commercial serological tests for SARS-CoV-2 on hospitalized COVID-19 patients”
C. Serre-Miranda*, C. Nobrega*, S. Roque*, J. Canto-Gomes, C. S. Silva, N. Vieira, P. Barreira-Silva, P. Alves-Peixoto, J. Cotter, A. Reis, M. Formigo, H. Sarmento, O. Pires, A. Carvalho, D. Y. Petrovykh, L. Diéguez, J. C. Sousa, N. Sousa, C. Capela, J. A. Palha, P. G. Cunha, M. Correia-Neves
Int. J. Inf. Dis. (2021). 104:661
DOI: 10.1016/j.ijid.2021.01.038
“High Dimensional Immune Profiling Reveals Different Response Patterns in Active and Latent Tuberculosis Following Stimulation with Mycobacterial Glycolipids”
C. S. Silva, C. Sundling, E. Folkesson, G. Fröberg, C. Nobrega, J. Canto-Gomes, B. J. Chambers, T. Lakshmikanth, P. Brodin, J. Bruchfeld, J. Nigou, M. Correia-Neves, G. Kallenius
Front. Immunol. (2021). 12:727300
DOI: 10.3389/fimmu.2021.727300
“Thymic function as a predictor of immune recovery in chronically HIV-infected patients initiating antiretroviral therapy”
R. Rb-Silva, C. Nobrega, C. Azevedo, E. Athayde, J. do Canto Gomes, I. Ferreira, R. Cheynier, A. Yates, A. Horta, M. Correia-Neves
Front. Immunol. (2019). 2:25
DOI: 10.3389/fimmu.2019.00025
Grants:
07/2022 Awardee, EMBO Scientific Exchange Grant, Funder: EMBO
Projects:
2025 (PI), “Unravelling T-Cell Dysfunction in Multiple Sclerosis: Can Plasma Hold the Key?”, Life and Health Sciences Research Institute (ICVS) University of Minho, Braga, Portugal; Funder: Fundação para a Ciência e a Tecnologia (FCT).
2022-2024 (Team member), “Tcells@MS-Why are peripheral T cells less mature at Multiple Sclerosis clinical onset?”, Life and Health Sciences Research Institute (ICVS) University of Minho, Braga, Portugal; Funder: Fundação para a Ciência e a Tecnologia (FCT).
2021-2024 (Team member), “Assessment of SARS-COV-2 vaccine response in patients with multiple sclerosis (COVACiMS)”, Funders: Grupo de Estudos em Esclerose Multipla (GEEM), Roche and Biogen.
2020-2021 (Team member), “Which, when and for who? Serodiagnosis as a tool to complement diagnosis and evaluate population immunity against SARS-CoV-2”, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal; Funder: Fundação para a Ciência e a Tecnologia (FCT).
2018-2020 (Team member), “Relation between regulatory T cells and immunological hyperactivation associated co-morbilities of chronically infected HIV-infected patients”, Life and Health Sciences Research Institute (ICVS) University of Minho, Braga, Portugal; Funder: Gilead Sciences Lda.