Jonathan Miguel Zanatta

  • leishmaniasis
  • macrophage
  • molecular-biology
  • lncRNAs
  • miRNAs
  • immunometabolism.

Jonathan Miguel Zanatta is a PhD student in the Immunology Program at the Institute of Biomedical Sciences, University of São Paulo (USP), in São Paulo, Brazil, and a member of the research group supervised by Dr. Sandra Marcia Muxel. He is now part of Dr. Ricardo Silvestre’s research group, as part of the BEPE-FAPESP international internship program, funded by the São Paulo Research Foundation. He completed his undergraduate degree in General Biology at Universidade Estadual do Norte do Paraná (2018) and earned his Master’s degree in Sciences – Physiology at the Institute of Biosciences, University of São Paulo (2022). During his Master’s, he investigated the impact of polyamines on host-parasite interactions. His current research focuses on the role of a long non-coding RNA during macrophage infection by Leishmania infantum, the causative agent of visceral leishmaniasis.

Jonathan Miguel Zanatta

  • leishmaniasis
  • macrophage
  • molecular-biology
  • lncRNAs
  • miRNAs
  • immunometabolism.

Jonathan Miguel Zanatta is a PhD student in the Immunology Program at the Institute of Biomedical Sciences, University of São Paulo (USP), in São Paulo, Brazil, and a member of the research group supervised by Dr. Sandra Marcia Muxel. He is now part of Dr. Ricardo Silvestre’s research group, as part of the BEPE-FAPESP international internship program, funded by the São Paulo Research Foundation. He completed his undergraduate degree in General Biology at Universidade Estadual do Norte do Paraná (2018) and earned his Master’s degree in Sciences – Physiology at the Institute of Biosciences, University of São Paulo (2022). During his Master’s, he investigated the impact of polyamines on host-parasite interactions. His current research focuses on the role of a long non-coding RNA during macrophage infection by Leishmania infantum, the causative agent of visceral leishmaniasis.

Scientific Highlights

Putrescine supplementation shifts macrophage L-arginine metabolism related-genes reducing Leishmania amazonensis infection
Zanatta JM, Acuña SM, de Souza Angelo Y, de Almeida Bento C, Peron JPS, et al. (2023) Putrescine supplementation shifts macrophage L-arginine metabolism related-genes reducing Leishmania amazonensis infection. PLOS ONE 18(3): e0283696. https://doi.org/10.1371/journal.pone.0283696

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Immunometabolic networks on Leishmania infection

Innate immune cells tightly coordinate their metabolic programs to support a proper immunological function. As such, perturbed metabolic fluxes imply decisive effects on immune cell activation eventuating in their ability to control a pathogen and the disease inflicted by it.

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