Jorge Diogo Silva is currently a Medical Genetics Resident at the Centro Hospitalar e Universitário de Santo António, and Invited Assitant Professor at the School of Medicine of the University of Minho. Throughout his career, he has engaged in several research activities, such as an Internship at Harvard Medical School/Massachusetts General Hospital and a continuous collaboration at the Life and Health Science Research Institute (ICVS; Braga, Portugal). He has pursued his Ph.D. studies on the topic of Neurogenetics, where he explored the usefulness of nematode models to study neurogenetic diseases, in both fundamental and translational perspectives, and has undertaken post-graduate training in Clinical Trial Regulation and Biostatistics. He has presented his work in several international meetings, having been awarded several scholarships and prizes for his research. He has also collaborated in research studies in both Fundamental and Clinical Medicine, currently with published work in Human Genetics, Epigenetics, Stem Cell Research, Neuroscience and Clinical Neurology. He currently has internationally funded research projects and supervises master and doctoral students. Moreover, he is involved in teaching activities for both medical, psychology and post-graduate students, in the areas of Genetics and Neurosciences. His goal is to synergistically bridge the areas of clinical care, medical research and teaching.
Jorge Diogo Silva is currently a Medical Genetics Resident at the Centro Hospitalar e Universitário de Santo António, and Invited Assitant Professor at the School of Medicine of the University of Minho. Throughout his career, he has engaged in several research activities, such as an Internship at Harvard Medical School/Massachusetts General Hospital and a continuous collaboration at the Life and Health Science Research Institute (ICVS; Braga, Portugal). He has pursued his Ph.D. studies on the topic of Neurogenetics, where he explored the usefulness of nematode models to study neurogenetic diseases, in both fundamental and translational perspectives, and has undertaken post-graduate training in Clinical Trial Regulation and Biostatistics. He has presented his work in several international meetings, having been awarded several scholarships and prizes for his research. He has also collaborated in research studies in both Fundamental and Clinical Medicine, currently with published work in Human Genetics, Epigenetics, Stem Cell Research, Neuroscience and Clinical Neurology. He currently has internationally funded research projects and supervises master and doctoral students. Moreover, he is involved in teaching activities for both medical, psychology and post-graduate students, in the areas of Genetics and Neurosciences. His goal is to synergistically bridge the areas of clinical care, medical research and teaching.
Articles
Da Silva, J. D., Oliveira, S., Pereira-Sousa, J., Teixeira-Castro, A., Costa, M. D., & Maciel, P. (2020). Loss of egli-1, the Caenorhabditis elegans Orthologue of a Downstream Target of SMN, Leads to Abnormalities in Sensorimotor Integration. Molecular neurobiology, 57(3), 1553–1569. https://doi.org/10.1007/s12035-019-01833-0
Da Silva, J. D., Teixeira-Castro, A., & Maciel, P. (2019). From Pathogenesis to Novel Therapeutics for Spinocerebellar Ataxia Type 3: Evading Potholes on the Way to Translation. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 16(4), 1009–1031. https://doi.org/10.1007/s13311-019-00798-1
Da Silva, J. D., Costa, M. D., Almeida, B., Lopes, F., Maciel, P., & Teixeira-Castro, A. (2021). Case Report: A Novel GNB1 Mutation Causes Global Developmental Delay With Intellectual Disability and Behavioral Disorders. Frontiers in neurology, 12, 735549. https://doi.org/10.3389/fneur.2021.735549
Bravo, F. V., Da Silva, J., Chan, R. B., Di Paolo, G., Teixeira-Castro, A., & Oliveira, T. G. (2018). Phospholipase D functional ablation has a protective effect in an Alzheimer’s disease Caenorhabditis elegans model. Scientific reports, 8(1), 3540. https://doi.org/10.1038/s41598-018-21918-5
Antunes, C., Da Silva, J. D., Guerra-Gomes, S., Alves, N. D., Ferreira, F., Loureiro-Campos, E., Branco, M. R., Sousa, N., Reik, W., Pinto, L., & Marques, C. J. (2021). Tet3 ablation in adult brain neurons increases anxiety-like behavior and regulates cognitive function in mice. Molecular psychiatry, 26(5), 1445–1457. https://doi.org/10.1038/s41380-020-0695-7
Mendes-Pinheiro, B., Anjo, S. I., Manadas, B., Da Silva, J. D., Marote, A., Behie, L. A., Teixeira, F. G., & Salgado, A. J. (2019). Bone Marrow Mesenchymal Stem Cells’ Secretome Exerts Neuroprotective Effects in a Parkinson’s Disease Rat Model. Frontiers in bioengineering and biotechnology, 7, 294. https://doi.org/10.3389/fbioe.2019.00294
Antunes, C., Da Silva, J. D., Guerra-Gomes, S., Alves, N. D., Loureiro-Campos, E., Pinto, L., & Marques, C. J. (2022). Tet3 Deletion in Adult Brain Neurons of Female Mice Results in Anxiety-like Behavior and Cognitive Impairments. Molecular neurobiology, 59(8), 4892–4901. https://doi.org/10.1007/s12035-022-02883-7
Meira-Carvalho, F., Da Silva, J. D., & Rodrigues, M. (2021). Opicapone in Parkinson’s Disease: Real-World Data from a Portuguese Center. European neurology, 84(2), 129–131. https://doi.org/10.1159/000514544
Funding and Awards
Prize for the Best Hot Chair Presentation at the 7th Ataxia Investigators Meeting (Philadelphia, PA, USA, 2018).
Our multidisciplinary research team aims at dentifying and validating novel genetic causes of neurodevelopmental disorders in human patients, taking advantage of clinically well characterized patient cohorts and…
Phone: +351 253 604 967
Fax: +351 253 604 809
Email: icvs.sec@med.uminho.pt
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
Copyright ©2022 ICVS. All Rights Reserved
Copyright ©2022 ICVS. All Rights Reserved
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
Copyright ©2022 ICVS. All Rights Reserved
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
