Leandro Rodrigues Freitas

  • Brain Plasticity
  • Astrogliogenesis
  • Stress
  • Electrophysiology

I am Leandro Freitas, a PhD student at ICVS. I concluded the BSc in Biotechnology at the University of Aveiro in 2021 where I did an internship at CICECO – Aveiro Institute of Materials and at the Department of Engineering and Materials, to explore the very first steps of a boron-doped diamond-based enzymatic biosensor for phenolic compounds with potential applications in monitoring neurologic biomarkers. Next, I completed the MSc in Biochemistry and Biomedicine in 2024 where I worked under the supervision of Dr. Sandra Vaz at Instituto de Medicina Molecular, Lisbon School of Medicine, in the project “Role of astrocytes in the endocannabinoid-mediated long-term depression in the medial prefrontal cortex (mPFC)“. Briefly, we proposed a new mechanism behind long-term depression (LTD) maintenance where astrocytes respond to endocannabinoids by increasing their intracellular Ca2+ frequency and decreasing glutamate uptake, ultimately shaping LTD (DOI:10.21203/rs.3.rs-4281560/v1). Next, I was awarded with a PhD Studentship (2024.01292.BDANA) by FCT, to develop the project “AstroMap: Understanding Adult Astrogliogenesis in Health and Depression”, under the supervision of Dr. Luisa Pinto, Dr. Sandra Vaz and Dr. Teresa Canedo.

Leandro Rodrigues Freitas

  • Brain Plasticity
  • Astrogliogenesis
  • Stress
  • Electrophysiology

I am Leandro Freitas, a PhD student at ICVS. I concluded the BSc in Biotechnology at the University of Aveiro in 2021 where I did an internship at CICECO – Aveiro Institute of Materials and at the Department of Engineering and Materials, to explore the very first steps of a boron-doped diamond-based enzymatic biosensor for phenolic compounds with potential applications in monitoring neurologic biomarkers. Next, I completed the MSc in Biochemistry and Biomedicine in 2024 where I worked under the supervision of Dr. Sandra Vaz at Instituto de Medicina Molecular, Lisbon School of Medicine, in the project “Role of astrocytes in the endocannabinoid-mediated long-term depression in the medial prefrontal cortex (mPFC)“. Briefly, we proposed a new mechanism behind long-term depression (LTD) maintenance where astrocytes respond to endocannabinoids by increasing their intracellular Ca2+ frequency and decreasing glutamate uptake, ultimately shaping LTD (DOI:10.21203/rs.3.rs-4281560/v1). Next, I was awarded with a PhD Studentship (2024.01292.BDANA) by FCT, to develop the project “AstroMap: Understanding Adult Astrogliogenesis in Health and Depression”, under the supervision of Dr. Luisa Pinto, Dr. Sandra Vaz and Dr. Teresa Canedo.

Scientific Highlights

Publications: 1 – Bernardo L. Tavares, Diogo R. Fernandes, Leandro Rodrigues-Freitas, João C.F. Nunes, Ana V. Girão, Márcia C. Neves, António J.S. Fernandes, Valéria C. Santos-Ebinuma, Miguel A.C. Neto, Ana P.M. Tavares, Simple adsorption-based immobilization of l-asparaginase on boron-doped diamond film, Surfaces and Interfaces, Volume 73, 2025, https://doi.org/10.1016/j.surfin.2025.107606. ; 2 – Leandro Rodrigues-Freitas, Luísa Pinto, Immuno-Golgi method – Integrating immunohistochemistry and Golgi staining to characterize newborn neurons morphology, Brain Organoid and Systems Neuroscience Journal, Volume 3, 2025, https://doi.org/10.1016/j.bosn.2025.10.001.  Honors and Awards: Merit and Excellence Scholarship 2024, Município de Fafe

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