Mathieu Lepas

  • Mycology
  • Aspergillus
  • glycobiology
  • innate immunity
  • humoral factors
  • host-pathogen interaction

Mathieu Lepas is a biomedical student specializing in medical mycology. He holds a bachelor’s degree in Science, Technology and Health from the University of Tours, and two Master’s degrees: one in Infectiology, Immunity, Vaccinology and Biomedicine (University of Tours, France) and another in Cellular and Molecular Biology, with a specialization in Parasitology and Mycology (Sorbonne University, Paris, France). His research experience includes internships at INRAe (Nouzilly, France) and Institut Pasteur (Paris, France), where he investigated host–pathogen interactions and contributed to a project characterizing the glycome and proteome of pathogenic Mucorales. He later worked as a Research Engineer at Institut Pasteur on a vaccine development platform targeting Aspergillus fumigatus, combining fungal cell wall biology with immunological applications. His focus was on purifying fungal polysaccharides and conjugating them to microcapsules to enhance interactions with antigen-presenting cells. In January 2025, he joined ICVS (University of Minho) through the FCT project 2022.06674.PTDC under the supervision of Drs. Agostinho Carvalho and Cristina Cunha, expanding his research into immunometabolism and fungal immunopathogenesis. Active in the scientific community, he is a member of the French Microbiology Society and serves on the steering committee of the Young Microbiologist National Network. He has presented at multiple national and international conferences and, to date, co-authored a book chapter in Springer Advances in Experimental Medicine and Biology and a research paper about antifungal screening published in mBio.

Mathieu Lepas

  • Mycology
  • Aspergillus
  • glycobiology
  • innate immunity
  • humoral factors
  • host-pathogen interaction

Mathieu Lepas is a biomedical student specializing in medical mycology. He holds a bachelor’s degree in Science, Technology and Health from the University of Tours, and two Master’s degrees: one in Infectiology, Immunity, Vaccinology and Biomedicine (University of Tours, France) and another in Cellular and Molecular Biology, with a specialization in Parasitology and Mycology (Sorbonne University, Paris, France). His research experience includes internships at INRAe (Nouzilly, France) and Institut Pasteur (Paris, France), where he investigated host–pathogen interactions and contributed to a project characterizing the glycome and proteome of pathogenic Mucorales. He later worked as a Research Engineer at Institut Pasteur on a vaccine development platform targeting Aspergillus fumigatus, combining fungal cell wall biology with immunological applications. His focus was on purifying fungal polysaccharides and conjugating them to microcapsules to enhance interactions with antigen-presenting cells. In January 2025, he joined ICVS (University of Minho) through the FCT project 2022.06674.PTDC under the supervision of Drs. Agostinho Carvalho and Cristina Cunha, expanding his research into immunometabolism and fungal immunopathogenesis. Active in the scientific community, he is a member of the French Microbiology Society and serves on the steering committee of the Young Microbiologist National Network. He has presented at multiple national and international conferences and, to date, co-authored a book chapter in Springer Advances in Experimental Medicine and Biology and a research paper about antifungal screening published in mBio.

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Projects

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Host-fungus interaction and disease pathogenesis

The reprogramming of cellular metabolism is a fundamental mechanism whereby immune cells respond to infection. The sensing of microbial ligands by myeloid cells promotes dynamic changes in host cell metabolism to deliver a rapid source of energy to support…

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