Paula Ludovico

  • Aging
  • Age-associated diseases
  • Proteostasis
  • Metabolism
  • Regulated cell death
  • Cancer
  • Acute Meyloid Leukemia
  • Cellular Models

Paula Ludovico graduated in Biology, University of Porto (1994) and did her Master thesis on Molecular Genetics at the University of Minho (1999). In 2002, she concluded her PhD in Biological Sciences at University of Minho. Since 2011, she is an Associate Professor with habilitation at School of Medicine and a Principal Investigator at the Health and Life Sciences Research Institute (ICVS), School of Medicine, University of Minho. Since 2019, she is the Pro-director for ICVS. Paula was a pioneer on the study of regulated cell death in yeast and fungi and has been using yeast as a eukaryotic model to address important scientific questions on cellular and molecular biology. Particularly, she has been exploiting the yeast chronological aging model to address important questions on proteostasis control during cellular aging. More recently, Paula Ludovico has been interested in another age-related disease, the acute myeloid leukemia (AML) and has been involved in many projects on diagnosis, pathogenesis (particularly on the role of autophagy and UPS), treatment and monitoring of AML. Her track record is currently mirrored by 86 publications in international peer-reviewed journals (>7000 citations and h-index=29, Scopus; March 2022) and 5 book chapters. She has been supported by funding agencies (e.g. FCT) and contracts with the industry (e.g., Amicus therapeutics and Novartis). She serves as an editorial board member for Cancers and Microbial Cell, and she has been an ad-hoc reviewer for more than 70 journals (e.g. Aging Cell, Cell Death and Differentiation, Autophagy and PNAS) and several funding agencies.

Paula Ludovico

  • Aging
  • Age-associated diseases
  • Proteostasis
  • Metabolism
  • Regulated cell death
  • Cancer
  • Acute Meyloid Leukemia
  • Cellular Models

Paula Ludovico graduated in Biology, University of Porto (1994) and did her Master thesis on Molecular Genetics at the University of Minho (1999). In 2002, she concluded her PhD in Biological Sciences at University of Minho. Since 2011, she is an Associate Professor with habilitation at School of Medicine and a Principal Investigator at the Health and Life Sciences Research Institute (ICVS), School of Medicine, University of Minho. Since 2019, she is the Pro-director for ICVS. Paula was a pioneer on the study of regulated cell death in yeast and fungi and has been using yeast as a eukaryotic model to address important scientific questions on cellular and molecular biology. Particularly, she has been exploiting the yeast chronological aging model to address important questions on proteostasis control during cellular aging. More recently, Paula Ludovico has been interested in another age-related disease, the acute myeloid leukemia (AML) and has been involved in many projects on diagnosis, pathogenesis (particularly on the role of autophagy and UPS), treatment and monitoring of AML. Her track record is currently mirrored by 86 publications in international peer-reviewed journals (>7000 citations and h-index=29, Scopus; March 2022) and 5 book chapters. She has been supported by funding agencies (e.g. FCT) and contracts with the industry (e.g., Amicus therapeutics and Novartis). She serves as an editorial board member for Cancers and Microbial Cell, and she has been an ad-hoc reviewer for more than 70 journals (e.g. Aging Cell, Cell Death and Differentiation, Autophagy and PNAS) and several funding agencies.

Scientific Highlights

1. Pioneer on the study of regulated cell death in yeast and fungi and has been using yeast as a eukaryotic model to address important scientific questions on cellular and molecular biology.

2. Pioneer on using the yeast chronological aging model to express human-disease related proteins to address proteostasis and nutrient sensing pathways control during cellular aging.

3. First description of the role of hydrogen peroxide on promoting longevity by using the cellular model yeast.

4. Contributor of the two last issues of “Guidelines for the use and interpretation of assays for monitoring autophagy (3rd and 4th editions)”.

5. Contribution for the study of the role of autophagy in acute myeloid leukemia.

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Projects

As Leader

Novel Biomarkers in Fabry disease Progression

Fabry disease (FD) a is multi-systemic, X-linked lysosomal storage disease caused by a range of mutations in the GLA gene that encodes for alpha-galactosidase A (α-gal A). Mutations leading to a deficient or absent activity of the enzyme α-gal A result in a progressive accumulation…

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Projects

As Member

Immunometabolic requirements in Buruli Ulcer

Mycobacterium ulcerans is the causative agent of Buruli Ulcer (BU), a neglected tropical disease characterized by extensive necrotic skin lesions. M. ulcerans, although an intracellular pathogen, is able to secrete a cytotoxic and immunosuppressive toxin – mycolactone…

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