Paula Ludovico

  • Aging and Cancer
  • Proteostasis and extracellular vesicles
  • Regulated Cell Death
  • Acute Meyloid Leukemia
  • Metabolism

Paula Ludovico graduated in Biology, University of Porto (1994), has Master thesis on Molecular Genetics, University of Minho (1999) and a PhD in Biological Sciences, University of Minho (2002). She is an Associate Professor with habilitation at School of Medicine and a Principal Investigator at the Health and Life Sciences Research Institute (ICVS), School of Medicine, University of Minho. From 2019-2023, she was the Pro-director for ICVS. Paula was a pioneer on the study of regulated cell death in yeast and has been using this eukaryotic model to address important questions on proteostasis and metabolism control during cellular aging. Paula Ludovico is also interested in an age-related disease, the acute myeloid leukemia, and has been involved in many projects on diagnosis, pathogenesis, treatment and monitoring of AML. Her track record is currently mirrored by 92 publications in international peer-reviewed journals (>9000 citations and h-index=32) and 5 book chapters. She has been supported by funding agencies and contracts with the industry (e.g., Amicus therapeutics and Novartis). She is an editorial board member for Cancers and Microbial Cell, and she has been an ad-hoc reviewer for more than 70 journals and several funding agencies.

Paula Ludovico

  • Aging and Cancer
  • Proteostasis and extracellular vesicles
  • Regulated Cell Death
  • Acute Meyloid Leukemia
  • Metabolism

Paula Ludovico graduated in Biology, University of Porto (1994), has Master thesis on Molecular Genetics, University of Minho (1999) and a PhD in Biological Sciences, University of Minho (2002). She is an Associate Professor with habilitation at School of Medicine and a Principal Investigator at the Health and Life Sciences Research Institute (ICVS), School of Medicine, University of Minho. From 2019-2023, she was the Pro-director for ICVS. Paula was a pioneer on the study of regulated cell death in yeast and has been using this eukaryotic model to address important questions on proteostasis and metabolism control during cellular aging. Paula Ludovico is also interested in an age-related disease, the acute myeloid leukemia, and has been involved in many projects on diagnosis, pathogenesis, treatment and monitoring of AML. Her track record is currently mirrored by 92 publications in international peer-reviewed journals (>9000 citations and h-index=32) and 5 book chapters. She has been supported by funding agencies and contracts with the industry (e.g., Amicus therapeutics and Novartis). She is an editorial board member for Cancers and Microbial Cell, and she has been an ad-hoc reviewer for more than 70 journals and several funding agencies.

Scientific Highlights

1. Pioneer on the study of regulated cell death in yeast and fungi and has been using yeast as a eukaryotic model to address important scientific questions on cellular and molecular biology.

2. Pioneer on using the yeast chronological aging model to express human-disease related proteins to address proteostasis and nutrient sensing pathways control during cellular aging.

3. First description of the role of hydrogen peroxide on promoting longevity by using the cellular model yeast.

4. Contributor of the two last issues of “Guidelines for the use and interpretation of assays for monitoring autophagy (3rd and 4th editions)”.

5. Contribution for the study of the role of autophagy in acute myeloid leukemia.

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Projects

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Projects

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