- Research
- Brain Circuits and Neuron-glia Adaptations
- Teresa Canedo
Teresa Canedo
- Brain Plasticity
- Adult Brain Cytogenesis
- Astrogliogenesis
- Hippocampus
- Depression
After graduating in Biology in 2012, I pursued a Master’s Degree in Forensic Medicine from the University of Porto, which I completed in 2014. During my Master’s thesis, I joined a research project at IBMC focused on the neurotoxic effects of psychostimulant drugs. This allowed me to later secure a research fellowship at i3S, where I developed robust technical skills and gained insights into the neurological effects of psychoactive substances. I also had the opportunity to collaborate in projects studying the impact of cytoskeleton-related proteins in microglia and, consequently, in brain homeostasis. In 2017, I started a PhD in Neurosciences at the Medical School of Porto (FMUP), supported by an FCT fellowship, where I unveiled the molecular mechanisms regulating psychostimulant-induced microglia activation, resulting in an first-author publication in Neuropsychopharmacology and co-authorship of nine research articles. In this study, I found that methamphetamine promotes astrocytic glutamate release in a IP3R2/Ca2+ signaling dependence, which is critical for microglia activation. In January 2022, I completed my PhD degree with a special distinction from FMUP. Currently, as a postdoctoral fellow, I am excited to integrate an innovative project aimed to selectively ablating adult-born and pre-existing astrocytes in the adult CNS, while preserving the neuronal lineage. In addition to my research, I embraced the responsibility of mentoring the next generation of scientists. I have guided several undergraduate and graduate students, fostering their development and contributing to their academic success. Furthermore, I have been actively involved in science outreach activities, delivering workshops such as “Smart Drugs-Cognitive Improvement” to high school students and participating in programs such as “Ciência Viva no Laboratório” and “Brain Awareness Week”.
Teresa Canedo
- Brain Plasticity
- Adult Brain Cytogenesis
- Astrogliogenesis
- Hippocampus
- Depression
After graduating in Biology in 2012, I pursued a Master’s Degree in Forensic Medicine from the University of Porto, which I completed in 2014. During my Master’s thesis, I joined a research project at IBMC focused on the neurotoxic effects of psychostimulant drugs. This allowed me to later secure a research fellowship at i3S, where I developed robust technical skills and gained insights into the neurological effects of psychoactive substances. I also had the opportunity to collaborate in projects studying the impact of cytoskeleton-related proteins in microglia and, consequently, in brain homeostasis. In 2017, I started a PhD in Neurosciences at the Medical School of Porto (FMUP), supported by an FCT fellowship, where I unveiled the molecular mechanisms regulating psychostimulant-induced microglia activation, resulting in an first-author publication in Neuropsychopharmacology and co-authorship of nine research articles. In this study, I found that methamphetamine promotes astrocytic glutamate release in a IP3R2/Ca2+ signaling dependence, which is critical for microglia activation. In January 2022, I completed my PhD degree with a special distinction from FMUP. Currently, as a postdoctoral fellow, I am excited to integrate an innovative project aimed to selectively ablating adult-born and pre-existing astrocytes in the adult CNS, while preserving the neuronal lineage. In addition to my research, I embraced the responsibility of mentoring the next generation of scientists. I have guided several undergraduate and graduate students, fostering their development and contributing to their academic success. Furthermore, I have been actively involved in science outreach activities, delivering workshops such as “Smart Drugs-Cognitive Improvement” to high school students and participating in programs such as “Ciência Viva no Laboratório” and “Brain Awareness Week”.
Scientific Highlights
Publications:
- Silva, A.I.; Socodato, R.; Pinto, C.; Terceiro, A.F.; Canedo, T.; Relvas, J.B.; Saraiva, M.; Summavielle, T. “IL-10 and Cdc42 modulate astrocyte-mediated microglia activation in methamphetamine-induced neuroinflammation”. Glia (2024): http://dx.doi.org/10.1002/glia.24542.
- Socodato, R.; Almeida, T.O.; Portugal, C.C.; Santos, E.C.S.; Tedim-Moreira, J.; Galvão-Ferreira, J.; Canedo, T.; et al. “Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance”. Cell Reports (2023): http://dx.doi.org/10.1016/j.celrep.2023.113447.
- Canedo, T.; Portugal, C.C.; Socodato, R.; Almeida, T. O.; Terceiro, A.F.; Bravo, J.; Silva, A.I.; et al. “Astrocyte-derived TNF and glutamate critically modulate microglia activation by methamphetamine”. Neuropsychopharmacology 46 13 (2021): 2358-2370. http://dx.doi.org/10.1038/s41386-021-01139-7. 10.1038/s41386-021-01139-7
- Socodato, R.; Henriques, J.F.; Portugal, C.C.; Almeida, T.O.; Tedim-Moreira, J.; Alves, R.L.; Canedo, T.; et al. “Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior”. Science Signaling (2020): https://doi.org/10.1126/scisignal.aba5754.
- Socodato, R.; Portugal, C.C.; Canedo, T.; Rodrigues, A.; Almeida, T.O.; Henriques, J.F.; Vaz, S.H.; et al. “Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration”. Cell Reports 31 12 (2020): 107796. http://dx.doi.org/10.1016/j.celrep.2020.107796.
Honours and Awards:
- First Place in the Travel Award: Neuro2022, Okinawa, Japan, 2022.
- PhD with Distinction: Faculty of Medicine of the University of Porto, Porto, Portugal, 2022.
- Cover: Neuropsychopharmacology, December 2021, Volume 46, Issue 13; Editorial note in Science: Leslie K. Ferrarelli. Tipsy microglia binge on synapses. Science 25 Sep 2020: Vol. 369, Issue 6511, pp. 1579; ttps://science.sciencemag.org/content/369/6511/twis.full; Altmetric score 312 – top 5% of all research outputs score.
- Cover: Science Signaling, September 2020, Volume 13, Issue 650
- Participating Fellowship: “XIV Meeting of the Portuguese Society for Neurosciences”, Póvoa de Varzim, Portugal, 2015.
Add Your Heading Text Here
Contact us
Phone: +351 253 604 967
Fax: +351 253 604 809
Email: icvs.sec@med.uminho.pt
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
Copyright ©2022 ICVS. All Rights Reserved
Copyright ©2022 ICVS. All Rights Reserved
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
Copyright ©2022 ICVS. All Rights Reserved
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal