Tiago Gonçalves

  • Drug resistance
  • Gene editing
  • PfMRP1
  • Plasmodium falciparum
  • Malaria
Tiago Gonçalves graduated in Biology from the University of Coimbra in 2023. During his degree, he developed a research project in the field of cancer biology at the Oncobiology and Hematology Laboratory of the Faculty of Medicine of the University of Coimbra, where he evaluated the therapeutic potential of the PARP inhibitor Niraparib in a Burkitt lymphoma cell line (Raji) by analyzing cell viability, cell cycle, and cell death.
In 2024, he enrolled in the Master’s Degree in Molecular Genetics at the School of Sciences of the University of Minho. He is currently working on his master’s thesis at the Life and Health Sciences Research Institute (ICVS), under the supervision of Isabel Veiga. His research project focuses on the study of the PfMRP1 transporter in Plasmodium falciparum and its role in the mechanisms of resistance to antimalarial drugs. To this end, he uses CRISPR/Cas9-based gene editing approaches to generate specific mutants and assess the impact of these changes on susceptibility to antimalarials and the transport of compounds associated with the folate pathway.

Tiago Gonçalves

  • Drug resistance
  • Gene editing
  • PfMRP1
  • Plasmodium falciparum
  • Malaria
Tiago Gonçalves graduated in Biology from the University of Coimbra in 2023. During his degree, he developed a research project in the field of cancer biology at the Oncobiology and Hematology Laboratory of the Faculty of Medicine of the University of Coimbra, where he evaluated the therapeutic potential of the PARP inhibitor Niraparib in a Burkitt lymphoma cell line (Raji) by analyzing cell viability, cell cycle, and cell death.
In 2024, he enrolled in the Master’s Degree in Molecular Genetics at the School of Sciences of the University of Minho. He is currently working on his master’s thesis at the Life and Health Sciences Research Institute (ICVS), under the supervision of Isabel Veiga. His research project focuses on the study of the PfMRP1 transporter in Plasmodium falciparum and its role in the mechanisms of resistance to antimalarial drugs. To this end, he uses CRISPR/Cas9-based gene editing approaches to generate specific mutants and assess the impact of these changes on susceptibility to antimalarials and the transport of compounds associated with the folate pathway.

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