Buruli ulcer: immunometabolic requirements for host-mycobacteria interaction
Mycobacterium ulcerans is the causative agent of Buruli Ulcer (BU), a neglected tropical disease characterized by extensive necrotic skin lesions. M. ulcerans, although an intracellular pathogen, is able to secrete a cytotoxic and immunosuppressive toxin – mycolactone. This apparent paradox of an intracellular lifestyle with the secretion of a cytotoxic toxin can be reconciled if one considers that metabolic cues can regulate mycolactone production, possibly by turning off the synthesis of mycolactone during intramacrophagic growth and later switching on toxin production for the lysis of the infected cell.
To fully understand the role of metabolism in the persistence and pathogenicity of M. ulcerans, the present proposal has two main goals: (1) perform the first global characterization of the host metabolic response during M. ulcerans infection and (2) regulate the main metabolic events that occur in the context of M. ulcerans infection to determine their impact on the immune response and the progression of infection.
Main Project Outcomes
S. Queirós, “Right ventricular segmentation in multi-view cardiac MRI using a unified U-net model”, in E. Puyol Antón et al. (eds) Statistical Atlases and Computational Models of the Heart. Multi-Disease, Multi-View, and Multi-Center Right Ventricular Segmentation in Cardiac MRI Challenge. STACOM 2021. Lecture Notes in Computer Science, vol 13131, pp. 287-295, Springer, Cham, 2022.
“Best Paper Award in the M&Ms-2 Challenge”, by M&Ms2 Challenge organizers and the Medical Image Computing and Computer Assisted Intervention (MICCAI) Society.