Tiago J. Dantas
Principal Investigator
Project Leader
Cell cycle control of neural stem cell proliferation during brain development
During development, embryonic neural stem cells known as radial glial progenitors (RGPs) generate most neurons and glia in the neocortex in a highly regulated fashion. RGPs are highly elongated cells, extending an apical process to the ventricular surface and a basal process that reaches the pial surface of the brain. The nuclei of RGPs undertake a remarkable cell cycle-regulated migratory behavior known as interkinetic nuclear migration (INM). Interestingly, during nuclear migration and throughout the cell cycle, the centrosome stays at the apical end-foot of the RGP cell, where it nucleates a primary cilium into the ventricular lumen of the brain. RGP proliferation requires proper ciliary assembly and signaling, yet how Dynein-2 regulates this process remains largely unknown and is the focus of this project…
Funding Agency
FCT
Funding Agency
FCT
Project Reference
POCI-01-0145-FEDER-029471 – Primary cilium-dependent cell cycle control of neural stem cell proliferation during brain development
Project Members
Main Project Outcomes
S. Queirós, “Right ventricular segmentation in multi-view cardiac MRI using a unified U-net model”, in E. Puyol Antón et al. (eds) Statistical Atlases and Computational Models of the Heart. Multi-Disease, Multi-View, and Multi-Center Right Ventricular Segmentation in Cardiac MRI Challenge. STACOM 2021. Lecture Notes in Computer Science, vol 13131, pp. 287-295, Springer, Cham, 2022.
“Best Paper Award in the M&Ms-2 Challenge”, by M&Ms2 Challenge organizers and the Medical Image Computing and Computer Assisted Intervention (MICCAI) Society.
Main Project Outcomes
The Dynein Adaptor RILP Controls Neuronal Autophagosome Biogenesis, Transport, and Clearance.
Khobrekar NV, Quintremil S, DANTAS TJ, Vallee RB.
Dev Cell. 2020 Apr 20;53(2):141-153.e4. doi: 10.1016/j.devcel.2020.03.011.
This work was selected for the cover of the issue (https://www.cell.com/developmental-cell/issue?pii=S1534-5807%2819%29X0009-X#fullCover) and highlighted in (https://noticias.up.pt/2020/05/13/i3s-ajuda-a-desvendar-proteina-que-explica-doencas-neurodegenerativas/)
Distinct Roles for Dynein Light Intermediate Chains in Neurogenesis, Migration, and Terminal Somal Translocation.
Gonçalves JC, DANTAS TJ, Vallee RB.
J Cell Biol. 2019 Mar 4;218(3):808-819. doi: 10.1083/jcb.201806112.
Doobin D*, Kemal S*, DANTAS TJ*, and Vallee RB. Severe NDE1-mediated Microcephaly Results from Neural Progenitor Cell Cycle Arrests at Multiple Specific Stages. Nature Commun. (2016); 7:12551. doi: 10.1038/ncomms12551 (featured in more than 11 news outlets)
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Life and Health Sciences
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University of Minho,
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Portugal
GPS: +41° 33′ 47.33″, -8° 24′ 3.39″
Copyright ©2025 ICVS. All Rights Reserved. Developed by TCIT
Copyright ©2025 ICVS. All Rights Reserved. Developed by TCIT
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
GPS: +41° 33′ 47.33″, -8° 24′ 3.39″
Copyright ©2025 ICVS. All Rights Reserved
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
GPS: +41° 33′ 47.33″, -8° 24′ 3.39″