about icvs | People | CLEAO


Name: Cecília Leão

Office: I1.05

School Phone: +351 253 604 823

Email: cleao@med.uminho.pt




Keywords: Microbiology Physiology Biochemistry Molecular Genetics Health Sciences


Cecilia Leão is a full Professor at the School of Health Sciences (ECS),University of Minho (UMinho). Presently, she is the ECS President and the Presidentof the Ethics Subcommittee for Life and Health Sciences of the UMinho.

Most of her research work has been devoted to the understanding of themechanisms involved in transmembrane transport of weak-organic acids in yeastand their involvement in stress. More recently, she is involved in researchfocusing on the elucidation of the molecular and cellular responses of yeaststo nutritional depletion and its involvement in cell death and aging. She haspublished more than 100 publications peer-reviewed research articles and book chaptersthat have been cited about 2000 times. Throughout the years she has been responsiblefor several research projects, funded by national and international agencies. Inthe scope of the research activity she has been responsible for the supervisionof more than 20 Master and 30 PhD theses.

Cecília Leão has been involved in the organization and scientificcommittee of several national and international meetings. She has alsointegrated several advisory boards, including the International Commission forYeasts, the Editorial Board of the international journals “Microbiology” and“FEMS Yeast Research”, the Scientific and Direction Committee of NationalMicrobiology Society and the Direction Committee of the National BiochemistrySociety. She has received several awards and honours for her researchaccomplishments, from which the most recent are: Member of the Academy forScience of Lisbon (Academia de Ciênciasde Lisboa) and Award Professor Nicolau van Uden 2013, Portuguese Societyfor Microbiology. 


Ammonium toxicity in yeast: different culture conditions with different nitrogen sources (Leader) 

Weak acid resistance in yeasts: better food preservative conditions and improvement of Saccharomyces cerevisiae fitness for industrial applications (Leader) 

Development of molecular tools in Paracoccidioides brasiliensis: towards identification and characterization of virulent factors  

Selected Publications

Mesquita A, Weinberger M, Silva A, Sampaio-Marques B, Almeida B, Leão C, Costa V, Rodrigues F, Burhans WC, Ludovico P. Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15123-8. doi: 10.1073/pnas.1004432107. Epub 2010 Aug 9.

Almeida B, Ohlmeier S, Almeida AJ, Madeo F, Leão C, Rodrigues F, Ludovico P. Yeast protein expression profile during acetic acid-induced apoptosis indicates causal involvement of the TOR pathway. Proteomics. 2009 Feb;9(3):720-32. doi: 10.1002/pmic.200700816.

Santos J, Sousa MJ, Leão C (2012) Ammonium Is Toxic for Aging Yeast Cells, Inducing Death and Shortening of the Chronological Lifespan. PLoS ONE 7(5): e37090. doi:10.1371/journal.pone.0037090

Sousa M, Duarte AM, Fernandes TR, Chaves SR, Pacheco A, Leão C, Côrte-Real M, Sousa MJ. Genome-wide identification of genes involved in the positive and negative regulation of acetic acid-induced programmed cell death in Saccharomyces cerevisiae. BMC Genomics. 2013 Nov 28;14:838. doi: 10.1186/1471-2164-14-838.

Rodrigues F, Sousa MJ, Ludovico P, Santos H, Côrte-Real M, Leão C. (2012) The Fate of Acetic Acid during Glucose Co-Metabolism by the Spoilage Yeast Zygosaccharomyces bailii. PLoS ONE 7(12): e52402. doi:10.1371/journal.pone.0052402

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