about icvs | People | PATRICIAPATRICIO


Name: Patrícia Patrício

Office: I202

School Phone: +351 253 604 839

Email: patriciapatricio@med.uminho.pt




Keywords: Neuroplasticity Depression Transcriptional regulation Epigenetics Pre-Clinical studies Cell Cycle


Patrícia Patrício is a post doc fellow at the Neuroscience Research Domain of the ICVS. Her work focuses on adult hippocampal neural plasticity in the context of depression and antidepressants.

She graduated in Applied Biology by the University of Minho and obtained a MSc in Molecular Genetics and Biomedicine by the New University of Lisbon, in 2010. 

In 2012, she co-founded the start up Bn'ML - Behavioral and Molecular Lab. Bn'ML offers 
customized preclinical behavioral and molecular analysis services for testing the potential of new therapeutic compounds. The company was awarded with the National Association of Young Entrepreneurs (ANJE) Prize, in 2013.

Patrícia completed a post graduation in Business Management and has received training in different areas of management and entrepreneurship.

She obtained her PhD in Health Sciences at the School of Health Sciences, in May 2016, under the supervision of Luísa Pinto, PhD, Osborne Almeida, PhD and Nuno Sousa, MD, PhD. Her PhD work focused on the molecular alterations underlying the neuroplastic phenomena occurring in the hippocampal neurogenic niche in the context of depression and after the treatment with different antidepressants, using a preclinical model.

Awards and Grants:


Invitation to participate in the Brain Prize Master Class on Translational Neuroscience, 10-12 April 2016, Copenhagen, Denmark


Poster presentation Award at the ECNP Workshop on Neuropsychopharmacology for Junior Scientists in Europe, Nice, France.


IBRO PERC-FENS World Congress Travel Grant Award


Travel Award for the ECNP Workshop on Neuropsychopharmacology for Junior Scientists in Europe, 12-15 March 2015, Nice, France


Young entrepreneur prize ANJE – BMLab – Behavioral and Molecular Lab; ANJE, Porto, Portugal


Portuguese Science and Technology Foundation (FCT) PhD fellowship



SpinUM: New Business Idea and Young Entrepreneurs Prize - BMLab – Behavioral and Molecular Lab; TecMinho, University of Minho, Braga, Portugal.

Selected Publications

Mateus-Pinheiro A, Patricio P, Bessa J, Sousa N, Pinto L. Cell genesis and dendritic plasticity: a neuroplastic pas de deux in the onset and remission from depression, Mol Psychiatry, 18:748-750 (2013).

Patrício P, Mateus-Pinheiro A, Irmler M, Alves ND, Machado-Santos AR, Morais M, Correia JS, Korostynski M, Piechota M, Stoffel R, Beckers J, Bessa JM, Almeida OF, Sousa N, Pinto L. Differential and converging molecular mechanisms of antidepressants action in the hippocampal dentate gyrus. Neuropsychopharmacology. 2015 Jan;40(2):338-49. doi: 10.1038/npp.2014.176. Epub 2014 Jul 18.

Patrício P, Mateus-Pinheiro A, Sousa N, Pinto L. Re-cycling Paradigms: Cell Cycle Regulation in Adult Hippocampal Neurogenesis and Implications for Depression. Mol Neurobiol, 2013 Aug;48(1):84-96.

Mateus-Pinheiro A, Patrício P, Alves ND, Machado-Santos AR, Morais M, Bessa JM, Sousa N. Pinto L. The Sweet Drive Test: Refining phenotypic characterization of anhedonic behavior in rodents. Front Behav Neurosc, 8:74 (2014).

Morais M, Santos P, Mateus-Pinheiro A, Patrício P, Pinto L, Sousa N, Pedroso P, Almeida S, Filipe A, Bessa JM. The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition. J Psychopharmacol, 28(12):1178-83 (2014).

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