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Name: António Mateus-Pinheiro

Office: I2.02

School Phone: +351 253 604 839

Email: apinheiro@med.uminho.pt

 

 

 

Keywords: Neuroplasticity Neurogenesis Gliogenesis Neuropsychiatric Disorders Epigenetics Animal Behavior

About

António Mateus-Pinheiro (MD PhD) graduated in Applied Biology, and subsequently in Medicine, by the University of Minho. António developed his master thesis in brain neural plasticity and repair in the context of stress-related disorders and their treatment.

Recently, in 2016, he got his PhD at the School of Medicine, University of Minho (Portugal), under the supervision of Dr. Luísa Pinto, PhD,  Professor Nuno Sousa, MD, PhD  and in collaboration with Dr. Miguel Branco, at the Blizard Institute, Queen Mary University of London (UK). The title of his PhD project is "Adult Hippocampal Neural Plasticity: insights into its relevance in the stressed and depressed brain". In his thesis, he studied the relevance of adult hippocampal neural plasticity (namely, dendritic remodeling and hippocampal neurogenesis and gliogenesis) in the healthy brain and in the context of stress-related disorders, such as Anxiety and Depression. He also performed a genome-wide analysis to identify epigenomic signatures controlling hippocampal neural plasticity. He received a project grant from Epigenesys European Network to conduct this study as a junior PI, in a collaborative work between the ICVS (Univ. of Minho, Portugal) and the Blizard Institute (Queen Mary Univ. of London, UK).

In 2012, he co-founded the ICVS spin-off BnML - Behavioral & Molecular Lab. BnML offers customized pre-clinical behavioral and molecular analysis services for testing the potential of new therapeutic compounds.



RESEARCH INTERESTS                                                       

Neuroplasticity (neurogenesis, gliogenesis, dendritic and synaptic plasticity); Neuroregeneration; Therapeutical Approaches; Transcriptional and epigenetic regulatory mechanisms; Animal Behavior; Science entrepreneurship  


CURRENT POSITION                                                             

Preclinical CNS Senior Researcher/ Consultant in BnML - Behavioral & Molecular Lab company.

MD PhD Researcher in the Life and Health Sciences Institute (ICVS), Neurosciences Research Domain, University of Minho

Associate and co-founder of BnML - Behavioral & Molecular Lab company (www.bnml.eu).


PUBLICATIONS & PATENTS                                                  

Mateus-Pinheiro A, Alves ND, Patrício P, Machado-Santos AR, Loureiro-Campos E, Silva JM, Sardinha VM, Reis J, Schorle H, Oliveira JF, Ninkovic J, Sousa  N  and Pinto L. AP2gamma controls adult hippocampal neurogenesis and modulates cognitive, but not anxiety or depressive-like behavior. Molecular Psychiatry, (2016). 

advanced online publication


Caetano L, Pinheiro H, Patrício P, Mateus-Pinheiro A, Alves ND, Coimbra B, Baptista FI, Henriques SN, Cunha C, Santos AR, Ferreira SG, Sardinha VM, Oliveira JF,

Ambrósio AF, Sousa N, Cunha RA, Rodrigues AJ, Pinto L and Gomes CA. Adenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety. Molecular Psychiatry, (2016). 

advanced online publication


Salgado AJ, Sousa JC, Costa BM, Pires AO, Mateus-Pinheiro A, Teixeira FG, Pinto L, Sousa N. Mesenchymal Stem Cells Secretome as a Modulator of the Neurogenic Niche: Basic Insights and Therapeutic Opportunities. Front Cell Neurosci, 9:249 (2015).

doi: 10.3389/fncel.2015.00249


Patrício P, Mateus-Pinheiro A, Irmler M, Alves ND, Machado-Santos AR, Morais M, Correia JS, Korostynski M, Piechota M, Stoffel R, Beckers J, Bessa JM, Almeida OF, Sousa N and Pinto L. Differential and Converging Molecular Mechanisms of Antidepressants' Action in the Hippocampal Dentate Gyrus. Neuropsychopharmacology, 40(2):338-49 (2015).

doi: 10.1038/npp.2014.176


Morais M, Santos P, Mateus-Pinheiro A, Patrício P, Pinto L, Sousa N, Pedroso P, Almeida S, Filipe A, Bessa JM. The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition. J Psychopharmacol, 28(12):1178-83 (2014).

doi: 10.1177/0269881114553646


Mateus-Pinheiro A, Patrício P, Alves ND, Machado-Santos AR, Morais M, Bessa JM, Sousa N, and Pinto L. The Sweet Drive Test: Refining phenotypic characterization of anhedonic behavior in rodents. Frontiers in Behavioral Neuroscience 8, 74 (2014). 

doi: 10.3389/fnbeh.2014.00074


Patrício P, Mateus-Pinheiro A, Sousa N, Pinto L. Re-cycling Paradigms: Cell Cycle Regulation in Adult Hippocampal Neurogenesis and Implications for Depression. Mol Neurobiol;48(1):84-96 (2013)

doi: 10.1007/s12035-013-8422-x


Mateus-Pinheiro A, Patrício P, Bessa JM, Sousa N, and Pinto L. Cell Genesis and Dendritic Plasticity: a Neuroplastic pas de deux in the onset and remission from depression. Molecular Psychiatry 18, 748-750 (2013)

doi: 10.1038/mp.2013.56


Mateus-Pinheiro A., Pinto L., Bessa J., Morais M., Alves D., Monteiro S., Patrício P., Almeida O., Sousa N. Sustained remission from depressive-like behavior depends on hippocampal neurogenesis. Translational Psychiatry 3,e210 (2013)

doi: 10.1038/tp.2012.141


Luísa Pinto, António Mateus Pinheiro, João Bessa, Mónica Morais, Nuno Sousa; Immuno-golgi as a tool for analyzing neuronal 3D-dendritic structure in a phenotypically characterized neurons; National Patent Number: 105555


Pinto L., Mateus-Pinheiro A., Morais M., Bessa J.M., Sousa N. Immuno-Golgi as a Tool for Analyzing Neuronal 3D- Dendritic Structure in Phenotypically Characterized Neurons. PlosOne 7(3): e33114 (2012).

doi: 10.1371/journal.pone.0033114


Mateus-Pinheiro A, Pinto L, Sousa N, Epigenetic (de)regulation of adult hippocampal neurogenesis: implications for depression; Clinical Epigenetics, 3:5 (2011)

doi: 10.1186/1868-7083-3-5.



PRIZES AND ACHIEVEMENTS                                            

2015 Society for Neuroscience Student Grant Award, Society for Neuroscience (SFN) 

2014 EpiGeneSys: Collaborative project grant, Epigenesys

2013 “Young Entrepreneurship of the Year”, National Association for Young Entrepreneurs  (ANJE) 

2012 “Best Spinoff Project - Behavioral & Molecular Lab (BnML)”, TechMinho

2009 Student with the highest mark in the Applied Biology course, University of Minho



Projects

Genetic and EpiGenetic orchestration of the adult brain neuroplasticity in health and depression  

Impact of proliferative, neurogenic and gliogenic modulatory events on the pathophysiology of Depression  

Selected Publications

Mateus-Pinheiro A, Patricio P, Bessa J, Sousa N, Pinto L. Cell genesis and dendritic plasticity: a neuroplastic pas de deux in the onset and remission from depression, Mol Psychiatry, 18:748-750 (2013).

Patrício P, Mateus-Pinheiro A, Irmler M, Alves ND, Machado-Santos AR, Morais M, Correia JS, Korostynski M, Piechota M, Stoffel R, Beckers J, Bessa JM, Almeida OF, Sousa N, Pinto L. Differential and converging molecular mechanisms of antidepressants action in the hippocampal dentate gyrus. Neuropsychopharmacology. 2015 Jan;40(2):338-49. doi: 10.1038/npp.2014.176. Epub 2014 Jul 18.

Patrício P, Mateus-Pinheiro A, Sousa N, Pinto L. Re-cycling Paradigms: Cell Cycle Regulation in Adult Hippocampal Neurogenesis and Implications for Depression. Mol Neurobiol, 2013 Aug;48(1):84-96.

Mateus-Pinheiro A, Patrício P, Alves ND, Machado-Santos AR, Morais M, Bessa JM, Sousa N. Pinto L. The Sweet Drive Test: Refining phenotypic characterization of anhedonic behavior in rodents. Front Behav Neurosc, 8:74 (2014).

Salgado AJ, Sousa JC, Costa BM, Pires AO, Mateus Pinheiro A, Teixeira FG, Pinto L, Sousa N. Mesenchymal Stem Cells Secretome as a Modulator of the Neurogenic Niche: Basic Insights and Therapeutic Opportunities. Front Cell Neurosci, 9:249 (2015).

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