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Research & Scientists | Neurosciences | People | MARTAPEREIRA

 

Name: Marta Viana-Pereira

Office: G1.28/I1.02

School Phone: +351 604 868 /37

Email: martapereira@med.uminho.pt

 

 

 

Keywords: Oncobiology

About

Post-doctoral research fellow at Life and Health Sciences Research Institute (ICVS), Schoolof Health Sciences,University of Minho, Braga, Portugal.

Graduated in Applied Biology in 2005, by the University of Minho, and completed the PhDin Health Sciences in March 2011, at School of Health Sciences, University of Minho. During the PhD was a Visiting Research Fellow at The Institute of Cancer Research, London, UK, under the supervision of Dr. Chris Jones.

Developed research works using different tumor models, having acquired broad experience in the Oncobiology research field. The domain of specialization is molecular characterization of therapeutic targets at the protein expression level; Mutational analysis and genotyping of polymorphisms; Cancer genetic instability and In vitro functional studies: 2D and 3D cell culture models.

Book Chapter Publications

Viana-Pereira M, Jones C, Reis RM. Genetic Instability in Pediatric and Adult Brain Tumors, in:Brain Tumor/Book 2, . pp. 19-42. InTech, 2011. ISBN 978-953-307-587-7.

Viana-Pereira M, Jones C, Reis RM. Pediatric High Grade Glioma: Role of Microsatellite Instability, in: Pediatric Cancer, Volume 3/Diagnosis, Therapy, and Prognosis,Part 4/Glioma, pp. 205-10. Springer, 2012. ISBN: 978-94-007-4527-8.

Projects

Development of 3D culture systems for in vitro study of tumour pathophysiology (Leader) 

Identification of novel target genes in microsatellite-unstable tumours  

Receptor tyrosine kinases (RTKs): signaling, biologic functions, and potential therapeutic targeting in solid tumors  

Selected Publications

Gaspar N, Marshall L, Perryman L, Bax DA, Little SE, Viana-Pereira M, Sharp SY, Vassal G, Pearson AD, Reis RM, Hargrave D, Workman P, Jones C. MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature. Cancer Res. 2010 Nov 15;70(22):9243-52. doi: 10.1158/0008-5472.CAN-10-1250. Epub 2010 Oct 8.

Bax DA, Mackay A, Little SE, Carvalho D, Viana-Pereira M, Tamber N, Grigoriadis AE, Ashworth A, Reis RM, Ellison DW, Al-Sarraj S, Hargrave D, Jones C. A distinct spectrum of copy number aberrations in pediatric high-grade gliomas. Clin Cancer Res. 2010 Jul 1;16(13):3368-77. doi: 10.1158/1078-0432.CCR-10-0438. Epub 2010 Jun 22.

Bax DA, Gaspar N, Little SE, Marshall L, Perryman L, Regairaz M, Viana-Pereira M, Vuononvirta R, Sharp SY, Reis-Filho JS, Stávale JN, Al-Sarraj S, Reis RM, Vassal G, Pearson AD, Hargrave D, Ellison DW, Workman P, Jones C. EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines. Clin Cancer Res. 2009 Sep 15;15(18):5753-61. doi: 10.1158/1078-0432.CCR-08-3210. Epub 2009 Sep 8.

Viana-Pereira M, Almeida I, Sousa S, Mahler-Araújo B, Seruca R, Pimentel J, Reis RM. Analysis of microsatellite instability in medulloblastoma. Neuro Oncol. 2009 Oct;11(5):458-67. doi: 10.1215/15228517-2008-115. Epub 2009 Jan 29.

Batista R*, Cruvinel-Carloni A*, Vinagre J*, Peixoto J, Catarino TA, Campanella NC, Menezes W, Becker AP, Caravina GA, Matsushita MM, Clara C, Neder L, Viana-Pereira M, Honavar M, Castro L, Lopes JM, Carvalho B, Vaz R, Máximo V, Soares P, Sobrinho-Simões M, Reis RM, Lima J. The prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism. International Journal of Cancer, 2016; 139(2): 414-423.

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