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Research & Scientists | People | NJCSOUSA

 

Name: Nuno Sousa

Office: G2.18

School Phone: +351 253 604 806

Email: njcsousa@med.uminho.pt

 

 

 

Keywords: stress neuroimaging neuropsychiatric disorders neuroanatomy sousa n

About

Nuno Sousa (MD, PhD) is Full Professor at the School of Health Science,University of Minho. He is the President of the School of Medicine at University of Minho. He serves at several medical education and medical assessment advisoryboards.

 

He is a NeuroRadiologist. Presently, he is the Director of the Clinical Academic Center at Hospital de Braga. He coordinates and is involved in several national and international research projects.

 

He is the Coordinator of the Neuroscience Research Domain at ICVS/University of Minho. His research main interests are focused in the establishment of functional and structural correlations mediated by stress and aging and its implications in cognition and in neuropsychiatric disorders. Detailed assessment of neuroplastic events, incorporation of newly generatedcells into neuronal networks, rearrangements of established dendritic andsynaptic contacts, combined with behavioural, neurochemical and eletrophysiogical, molecular biology and (epi)genetics correlates have been established in his laboratory; the work from the lab covers from basic to clinical research and several modulatory interventions have also been described in order to promote recovery of structure and function in neuronal tissues.

 

Nuno Sousa has published more than 300 peer-reviewed research articles (H-factor=54, >10000 citations). In addition to academic merits, Nuno Sousa serves on several science policy and advisory board positions, and as an Ad hoc reviewerfor various neuroscience journal and international funding organizations. He is Editor-in-Chief of Frontiers in Behavioral Neuroscience and Member of the Editorial Board of Molecular Neurodegeneration, Neurobiology of Stress and Neuropharmacology.

 

From 2011-15 Nuno Sousa was the President of the Portuguese Society for Neuroscience.

From 2014-2016, he was the President of the Scientific Council of Health and Life Sciences at FCT.

 

 

Honors and Prizes

GrunenthalPrize 2003 – Grunenthal Foundation

GrunenthalPrize 2007 – Grunenthal Foundation

2010Prize of the Portuguese Society of Human Genetics

GoldMedal of the Minister of Health, 2011

JanssenNeuroscience Prize, 2012

University of Minho Prize, 2013

 

 

10 SelectedPeer-reviewed Publications (Selected from 312 peer-reviewed publications;H-factor-54)

       N.Sousa, N. Lukoyanov, M.D. Madeira, O.F.X. Almeida, M.M. Paula-Barbosa.Reorganization of the morphology of hippocampal neurites and synapses afterstress-induced damage correlates with behavioral improvement. Neuroscience, 97: 253-266, 2000.


·      J.J. Cerqueira, F. Maillet, O.F.X. Almeida, T.M.Jay, N. Sousa. The prefrontalcortex as a key target of the maladaptive response to stress. Journal of Neuroscience 27:2781-2787,2007.


       E Dias-Ferreira, JC Sousa, I Melo, P Morgado, AR Mesquita, JJ Cerqueira, RMCosta, N Sousa. Chronic stress causes frontostriatal reorganizationand affects decision-making. Science,325:621-5, 2009.


·      JM Bessa, D. Ferreira, I. Melo, F. Marques, JJ.Cerqueira, JA Palha, OFX. Almeida, N. Sousa. The mood-improving actions of antidepressants do not depend onneurogenesis but are associated with neuronal remodeling. Molecular Psychiatry 14:764-73 2009.

·            JM Soares, ASampaio, LM Ferreira, NC Santos, F Marques, JA Palha, JJ Cerqueira, N Sousa.Stress-induced changes in human decision-making are reversible. Translational Psychiat, 2:e131, 2012.

      Lima A, Sardinha VM, Oliveira AF, Reis M,Mota C, Silva MA, Marques F, Cerqueira JJ, Pinto L, Sousa N, Oliveira JF.       ·       Oliveira TG, Chan RB,Bravo FV, Miranda A, Silva RR, Zhou B, Marques F, Pinto V, Cerqueira JJ, DiPaolo G, Sousa N. The impact of chronic stress on the rat brain lipidome. Molecular Psychiatry (in press), 2016.


Projects

Maintaining health in old age through homeostasis (Switchbox) (Leader) 

MyHealth (Leader) 

Reward circuit: from genes to neurons to behavior (Leader) 

BNST – Bridging aNxiety, Stress and addicTion  

Characterization of phospholipase D knock-out animal models  

Communication across the barriers  

Cumulative stress: the link between depression and dementia  

Environmental stress and Alzheimer´s disease pathologies  

Epigenetic regulators of pluripotency and neuronal differentiation and function  

Exploring the Therapeutic Potential of the Secretome of Mesenchymal Stem Cells in CNS Regenerative Medicine  

Genetic and EpiGenetic orchestration of the adult brain neuroplasticity in health and depression  

Impact of chronic stress on brain spliceosome – implications for neurodegeneration  

Impact of proliferative, neurogenic and gliogenic modulatory events on the pathophysiology of Depression  

Long term impact of prenatal glucocorticoid exposure (Human study)  

Multidisciplinary Strategies for Spinal Cord Injury Repair  

Obsessive-compulsive disorder: focus on stress and decision-making  

Sensomotor mechanisms and Alzheimer´s disease pathology  

The role of brain lipid metabolism in the modulation of chronic stress effects  

The role of the immune system in mood disorders and cognition  

Translation of neuron-astrocyte interactions in complex cognitive functions in health and disease  

Selected Publications

Dias-Ferreira E, Sousa JC, Melo I, Morgado P, Mesquita AR, Cerqueira JJ, Costa RM, Sousa N. Chronic stress causes frontostriatal reorganization and affects decision-making. Science. 2009 Jul 31;325(5940):621-5. doi: 10.1126/science.1171203.

Oliveira JM, Salgado AJ, Sousa N, Mano JF, Reis RL. Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies-A review. Progress in Polymer Science. 2010 Nov; 35(9): 1163-94. doi: 10.1016/j.progpolymsci.2010.04.006

Mateus-Pinheiro A, Patricio P, Bessa J, Sousa N, Pinto L. Cell genesis and dendritic plasticity: a neuroplastic pas de deux in the onset and remission from depression, Mol Psychiatry, 18:748-750 (2013).

Sousa N, Almeida OF. Disconnection and reconnection: the morphological basis of (mal)adaptation to stress. Trends Neurosci. 2012 Dec;35(12):742-51. doi: 10.1016/j.tins.2012.08.006. Epub 2012 Sep 21.

Oliveira J, Sardinha VM, Guerra-Gomes S, Araque A, Sousa N. Do stars govern our actions? Astrocyte involvement in rodents’ behavior. Trends Neurosci, 38(9):535-549 (2015).

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