Name: Nuno Sousa
School Phone: +351 253 604 806
Nuno Sousa (MD, PhD) is Full Professor at the School of Health Science,University of Minho. He is the Director of the Medical Degree at University ofMinho. He serves at several medical education and medical assessment advisoryboards.
He is a NeuroRadiologist. Presently, he is theDirector of the Clinical Academic Center at Hospital de Braga. He coordinates and is involved in several national and international research projects.
He is the Coordinator of the Neuroscience ResearchDomain at ICVS/University of Minho. His research main interests are focused inthe establishment of functional and structural correlations mediated by stress andaging and its implications in cognition and in neuropsychiatric disorders.Detailed assessment of neuroplastic events, incorporation of newly generatedcells into neuronal networks, rearrangements of established dendritic andsynaptic contacts, combined with behavioural, neurochemical andelectrophysiogical, molecular biology and (epi)genetics correlates have beenestablished in his laboratory; the work from the lab covers from basic toclinical research and several modulatory interventions have also been describedin order to promote recovery of structure and function in neuronal tissues.
Nuno Sousa has published more than 250 peer-reviewedresearch articles (in December 2015, h-factor=40, >5500 citations). In addition to academic merits, Nuno Sousa serves on several science policy and advisory board positions, and as an Ad hoc reviewerfor various neuroscience journal and international funding organizations. He is Editor-in-Chief of Frontiers in Behavioral Neuroscience and Member of the Editorial Board of Molecular Neurodegeneration and Neurobiology of Stress.
From 2011-15 Nuno Sousa was the President of the Portuguese Society for Neuroscience.
He is currently the President of the Scientific Council of Health and Life Sciences at FCT.
Honors and Prizes
GrunenthalPrize 2003 – Grunenthal Foundation
GrunenthalPrize 2007 – Grunenthal Foundation
2010Prize of the Portuguese Society of Human Genetics
GoldMedal of the Minister of Health, 2011
JanssenNeuroscience Prize, 2012
University of Minho Prize, 2013
10 SelectedPeer-reviewed Publications (Selected from 262 peer-reviewed publications;H-factor-40)
N.Sousa, N. Lukoyanov, M.D. Madeira, O.F.X. Almeida, M.M. Paula-Barbosa.Reorganization of the morphology of hippocampal neurites and synapses afterstress-induced damage correlates with behavioral improvement. Neuroscience, 97: 253-266, 2000.
· J.J. Cerqueira, F. Maillet, O.F.X. Almeida, T.M.Jay, N. Sousa. The prefrontalcortex as a key target of the maladaptive response to stress. Journal of Neuroscience 27:2781-2787,2007.
E Dias-Ferreira, JC Sousa, I Melo, P Morgado, AR Mesquita, JJ Cerqueira, RMCosta, N Sousa. Chronic stress causes frontostriatal reorganizationand affects decision-making. Science,325:621-5, 2009.
· JM Bessa, D. Ferreira, I. Melo, F. Marques, JJ.Cerqueira, JA Palha, OFX. Almeida, N. Sousa. The mood-improving actions of antidepressants do not depend onneurogenesis but are associated with neuronal remodeling. Molecular Psychiatry 14:764-73 2009.
· JM Soares, ASampaio, LM Ferreira, NC Santos, F Marques, JA Palha, JJ Cerqueira, N Sousa.Stress-induced changes in human decision-making are reversible. Translational Psychiat, 2:e131, 2012.
Lima A, Sardinha VM, Oliveira AF, Reis M,Mota C, Silva MA, Marques F, Cerqueira JJ, Pinto L, Sousa N, Oliveira JF. · Oliveira TG, Chan RB,Bravo FV, Miranda A, Silva RR, Zhou B, Marques F, Pinto V, Cerqueira JJ, DiPaolo G, Sousa N. The impact of chronic stress on the rat brain lipidome. Molecular Psychiatry (in press), 2016.
Dias-Ferreira E, Sousa JC, Melo I, Morgado P, Mesquita AR, Cerqueira JJ, Costa RM, Sousa N. Chronic stress causes frontostriatal reorganization and affects decision-making. Science. 2009 Jul 31;325(5940):621-5. doi: 10.1126/science.1171203.
Oliveira JM, Salgado AJ, Sousa N, Mano JF, Reis RL. Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies-A review. Progress in Polymer Science. 2010 Nov; 35(9): 1163-94. doi: 10.1016/j.progpolymsci.2010.04.006
Mateus-Pinheiro A, Patricio P, Bessa J, Sousa N, Pinto L. Cell genesis and dendritic plasticity: a neuroplastic pas de deux in the onset and remission from depression, Mol Psychiatry, 18:748-750 (2013).
Sousa N, Almeida OF. Disconnection and reconnection: the morphological basis of (mal)adaptation to stress. Trends Neurosci. 2012 Dec;35(12):742-51. doi: 10.1016/j.tins.2012.08.006. Epub 2012 Sep 21.
Oliveira J, Sardinha VM, Guerra-Gomes S, Araque A, Sousa N. Do stars govern our actions? Astrocyte involvement in rodents’ behavior. Trends Neurosci, 38(9):535-549 (2015).