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Research & Scientists | Surgical Sciences | People | MARTAFCOSTA

 

Name: Marta Costa

Office:

School Phone: +351

Email: martafcosta@med.uminho.pt

 

 

 

Keywords: Cancer Breast Cancer Renal Cell Carcinoma Cancer Targeted Therapy Medicinal Chemistry Chromene scaffold

About

Marta Costa is a Researcher working at the Life and Health Sciences Research Institute (ICVS), in the Schoolof Medicine (EM) - University of Minho. She holds a degree in Applied Chemistry by the University of Minho (2006) and completed her PhD in Sciences – Organic Chemistry in 2011, by the University of Minho, during this work she was awarded a PhD grant from the Portuguese Science Foundation (FCT). Marta has experience working as a Medicinal Chemist in a pharmaceutical company (Bial, 2011) and has also postdoctoral experience at the Chemistry Department at the University of Minho (Portugal, 2012-2014),working in organic synthesis and also in teaching under-graduated students. Marta joined the ICVS in 2015, as a post-doctoral fellow (2015-2019) and she is currently a Researcher, with a multidisciplinary profile, at the same Institute.

In the last years, Marta has focused her interest on the study of new synthetic molecules, mainly chromene-based compounds, as anticancer agents. She is particularly interested in finding novel and targeted therapies, especially for triple negative breast cancer and renal cell carcinoma, two types of aggressive cancers with poor therapeutic outcomes and, in terms of worldwide statistics, that will increase their incidence in the next years. She uses appropriate in vitro and in vivo cancer cell models to investigate the mechanism of action of the new compounds.

Marta has published several international peer-reviewed research articles, book chapters and she is the major inventor of 2 European patents (EP20166501.5 and EP20166887.8, pending). She supervised 9 Master thesis and several under-graduated research projects. Her research team has been acknowledged with several national and international awards, including a research grant from the “Liga Portuguesa Contra o Cancro” in 2019.


Selected Publications

Pontes O, Costa M, Santos F, Sampaio-Marques B, Dias T, Ludovico P, Baltazar F, Proença F. Exploitation of new chalcones and 4H-chromenes as agents for cancer treatment. European Journal of Medicinal Chemistry, 2018, 157, 101-114. 

Costa M, Dias T, Brito T, Proença F. Biological importance of structurally diversified chromenes. European Journal of Medicinal Chemistry, 2016, 123, 487-507.

Lima CF, Costa M, Proença M, Pereira-Wilson C. Novel structurally similar chromene derivatives with opposing effects on p53 and apoptosis mechanisms in colorectal HCT116 cancer cells. European Journal of Pharmaceutical Sciences, 2015, 72, 34-45.

Costa M., Rodrigues AI, Proença F. Synthesis of 3-aminochromenes: the Zincke reaction revisited. Tetrahedron, 2014, 70, 4869–4875.

Areias F, Costa M, Castro M, Brea J, Gregori-Puigjané E, Mestres J, Proença F, Loza M. New chromene scaffolds for adenosine A2A receptors: synthesis,pharmacology and structure-activity relationships. European Journal of  Medicinal Chemistry, 2012, 54, 303–310.

Proença F, Costa M. A simple and eco-friendly approach for the synthesis of 2-imino and 2-oxo-2H-chromene-3-carboxamides. Green Chemistry, 2008, 10, 995-998.

Costa M, Areias F, Abrunhosa L, Venâncio A,Proença F. The condensation of salicylaldehydes and malononitrile revisited: synthesis of new dimeric chromene derivatives. Journal of Organic Chemistry, 2008, 73, 1954-1962.


Book Chapters

Costa M, Proença F. Comprehensive Organic Chemistry Experiments for the Laboratory Classroom4.2. 3.6. A Simple and Ecological Preparation of a Chromene-3-carboxamide Derivative, Royal Society of Chemistry, 2017, 387.

Selected Publications

Costa M, Dias TA, Brito A, Proença F. Biological importance of structurally diversified chromenes. European Journal of Medicinal Chemistry, 2016; 123: 487–507.

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