Samuel M Gonçalves

  • Immunology
  • Infectious Diseases
  • Fungal infection
  • Immunometabolism
  • Personalized Medicine

Samuel Gonçalves graduated in Applied Biology (2015) and completed a Master’s degree (2017) and a PhD (2023) in Health Sciences from the University of Minho. Currently, he is a postdoctoral researcher focused on the elucidation of the effects of interindividual genetic variation on molecular and cellular processes of immunity and inflammation, and on translating this information into personalized medical interventions for fungal disease. Moreover, his research interests also focus on the role of human metabolism—particularly macrophage metabolism—in modulating immune responses in individuals at elevated risk for invasive fungal infections. He has been participating in the teams of multiple research projects on the host-fungus interaction, including past and ongoing grants funded by the EU, “la Caixa” Foundation, FCT, Gilead Sciences, and the European Society for Clinical Microbiology and Infectious Diseases (ESCMID). His has secured research funding through competitive grant calls from FCT and ESCMID. His commitment to scientific excellence was recently recognized with the conferment of the ‘Maria de Sousa Award’ (2024). He has been actively involved in the supervision of undergraduate students, particularly those enrolled in BSc programs in Applied Biology and Biochemistry, as well as medical students during their laboratory rotations and Master’s students from the Biomedicine program.

Samuel M Gonçalves

  • Immunology
  • Infectious Diseases
  • Fungal infection
  • Immunometabolism
  • Personalized Medicine

Samuel Gonçalves graduated in Applied Biology (2015) and completed a Master’s degree (2017) and a PhD (2023) in Health Sciences from the University of Minho. Currently, he is a postdoctoral researcher focused on the elucidation of the effects of interindividual genetic variation on molecular and cellular processes of immunity and inflammation, and on translating this information into personalized medical interventions for fungal disease. Moreover, his research interests also focus on the role of human metabolism—particularly macrophage metabolism—in modulating immune responses in individuals at elevated risk for invasive fungal infections. He has been participating in the teams of multiple research projects on the host-fungus interaction, including past and ongoing grants funded by the EU, “la Caixa” Foundation, FCT, Gilead Sciences, and the European Society for Clinical Microbiology and Infectious Diseases (ESCMID). His has secured research funding through competitive grant calls from FCT and ESCMID. His commitment to scientific excellence was recently recognized with the conferment of the ‘Maria de Sousa Award’ (2024). He has been actively involved in the supervision of undergraduate students, particularly those enrolled in BSc programs in Applied Biology and Biochemistry, as well as medical students during their laboratory rotations and Master’s students from the Biomedicine program.

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Projects

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Functional genomics of fungal disease

Genetic analysis of molecular and functional traits in immune cells, such as gene and protein expression and effector functions, offers a promising strategy for investigating phenotypic variation and dissecting the molecular mechanisms underlying propensity to infection.

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Host-fungus interaction and disease pathogenesis

The reprogramming of cellular metabolism is a fundamental mechanism whereby immune cells respond to infection. The sensing of microbial ligands by myeloid cells promotes dynamic changes in host cell metabolism to deliver a rapid source of energy to support…

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Lung microbiome and mucosal immunity

Recent studies have successfully implicated several factors in the susceptibility to fungal infection, but have provided little insight into the nature of the underlying biological mechanisms. We propose a multiomics approach to link deep clinical phenotyping…

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