Lactate metabolism and signalling in cancer
Reprogramming of energy metabolism is a key hallmark of cancer. Most cancer cells undergo the Warburg effect, with enhanced glycolytic metabolism and lactate production, which provides…
- Research
- Cancer Biomarkers and Therapeutics
- Sara Granja
Sara Granja
- Monocarboxylate transporters
- CD147
- Tumor associated macrophages
- Lactate
Sara Granja (SG), is a pos-doctoral research at ICVS/3Bs, University of Minho since January of 2014 and Invited Assistant Professor, at Escola Superior de Saúde from Instituto Politécnico do Porto since 2020. SG is graduated in Pathological Cytological and Thanatology Anatomy, concluded her master thesis in 2009 and her PhD in Health Sciences at the School of Medicine from the University of Minho in 2013. During her scientific career, SG provided significant contributions to the research field of oncobiology with a special focus on tumor metabolism, namely MCTs/CD147 as potential therapeutic targets in solid tumors. Besides ICVS, SG had the opportunity to work in two top leading groups in the area of tumor metabolism and inflammation, one led by Jacques Pouysségur (IRCAN, Nice) and other by Massimiliano Mazzone (VIB, Leuven). Recently SG started to expand the expertise to a new field of research the OncoImmunology. Her research topic is focused on elucidating how tumor-infiltrating immune cells are educated by the tumor microenvironment, with a particular focus on metabolism. SG (h-index =17) has authored or co-authored 33 papers in international peer-reviewed international journals and 4 book chapters and has the opportunity to supervise several students (Bachelor, Master and PhD students and medical students training within the MD/PhD program. SG interested research topics are cancer metabolism and imunometabolism.
Sara Granja
- Monocarboxylate transporters
- CD147
- Tumor associated macrophages
- Lactate
Sara Granja (SG), is a pos-doctoral research at ICVS/3Bs, University of Minho since January of 2014 and Invited Assistant Professor, at Escola Superior de Saúde from Instituto Politécnico do Porto since 2020. SG is graduated in Pathological Cytological and Thanatology Anatomy, concluded her master thesis in 2009 and her PhD in Health Sciences at the School of Medicine from the University of Minho in 2013. During her scientific career, SG provided significant contributions to the research field of oncobiology with a special focus on tumor metabolism, namely MCTs/CD147 as potential therapeutic targets in solid tumors. Besides ICVS, SG had the opportunity to work in two top leading groups in the area of tumor metabolism and inflammation, one led by Jacques Pouysségur (IRCAN, Nice) and other by Massimiliano Mazzone (VIB, Leuven). Recently SG started to expand the expertise to a new field of research the OncoImmunology. Her research topic is focused on elucidating how tumor-infiltrating immune cells are educated by the tumor microenvironment, with a particular focus on metabolism. SG (h-index =17) has authored or co-authored 33 papers in international peer-reviewed international journals and 4 book chapters and has the opportunity to supervise several students (Bachelor, Master and PhD students and medical students training within the MD/PhD program. SG interested research topics are cancer metabolism and imunometabolism.
Scientific Highlights
Publications
1.Sara Granja*, Adhemar Longatto-Filho*, Priscila B. de Campos, Claudia P. Oliveira, José T. Stefano, Sebastião N. Martins-Filho, Aline L. Chagas, Paulo Herman, Luiz C. D’Albuquerque, Mário Reis Alvares-d Silva, Flair J. Carrilho, Fátima Baltazar, Venancio A. F. Alves. Non-Alcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma: Immunohistochemical Assessment of Markers of Cancer Cell Metabolism. Pathobiology 2022 Jan 18;1-9. doi: 10.1159/000521034
2- Nathália Ferreira, Inês Mesquita, Fátima Baltazar, Ricardo Silvestre, Sara Granja*. IL-17A and IL-17F orchestrate macrophages to promote lung cancer. Cell Oncol (Dordr) 2020 Aug;43(4):643-654
3. Baltazar, Fátima; Afonso, Julieta; Costa, Marta; Granja, Sara. Lactate beyond a waste metabolite: metabolic affairs and signaling in malignancy. Frontiers in Oncology 2020 Mar 18;10:231 (IF=6.24)
4. Riera-Domingo C, Audigé A, Granja S, Cheng WC, Ho PC, Baltazar F, Stockmann C, Mazzone M. Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy. Physiol Rev. 2020 Jan 1;100(1):1-102. (IF=37.31)
5. Santos, Nuno; Pereira-Nunes, Andreia; Baltazar, Fátima; Granja, Sara*. Lactate as a Regulator of Cancer Inflammation and Immunity. 2019;1:e190015
6. Sara Granja, Ibtissam Marchiq, Renaud Le Floch, Conceição Souto-Moura, Fátima Baltazar and Jacques Pouysségur. Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status. Oncotarget, 2015, 30.6(9): 6708-21 (IF=5.008)
Posters:
1. AP Nunes, H.Ferreira, N.M.Neves, F.Baltazar, Granja S; “Disruption of cancer cell metabolism using targeted drug delivery systems”. Paper presented in LPCC, Virtual Conference, 2020.
2. Nunes, AP; Ferreira, H; Neves M Nuno; Baltazar, F; Granja, S.. “Targeting Cancer Cell Metabolism Using Targeted Drug Delivery Systems”. Paper presented in 25th Porto Cancer meeting, 2018.
3. Granja, Sara; Costa, Sandra; Baltazar F. “Cancer cell-macrophage metabolic symbiosis: unravelling the role of monocarboxylate transporters (MCTs)”. Paper presented in FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications, 2017.
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Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
GPS: +41° 33′ 47.33″, -8° 24′ 3.39″
Copyright ©2022 ICVS. All Rights Reserved
Copyright ©2022 ICVS. All Rights Reserved
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
GPS: +41° 33′ 47.33″, -8° 24′ 3.39″
Copyright ©2022 ICVS. All Rights Reserved
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
GPS: +41° 33′ 47.33″, -8° 24′ 3.39″