Ana Coelho

  • neuroimaging
  • aging
  • diffusion MRI
  • tractography
  • machine learning
  • connectivity-based parcellation

Ana Coelho has a PhD in Health Sciences and a master’s degree in Biomedical Engineering with a specialization in Medical Informatics. During her masters’ dissertation, she worked in the 3D reconstruction of bone structures from planar radiography images. This work continued through an internship at a startup (PeekMed) whose main goal is to develop a software to help physicians in pre-operative planning of orthopedic surgeries. There, she developed her expertise in computer vision and image processing. After this internship, she moved to the neurosciences field and started her research career. First, she started working as a research technician in the project “Pharmacogenetics study of the answer to treatment in Attention-Deficit/Hyperactivity Disorder and in Obsessive Compulsive Disorder” (an international collaboration between University of Minho and Fundación Publica Galega de Medicina Xenómica). Her main activity was the analysis of functional Magnetic Resonance Imaging (fMRI) data. Alongside with this job, she was also participating in other projects from the Life and Health Sciences Research Institute (ICVS, Braga, Portugal). Then, she started her PhD project at ICVS, which was focused in finding MRI biomarkers of cognitive preservation and decline in healthy aging. She developed her skills in neurosciences, statistics, research methodologies and machine learning. Moreover, she specialized in the analysis of diffusion weighted imaging and structural data. She also developed new analytical tools which helped reveal new insights about brain’s connectivity in aging and that are published in international peer-reviewed journals (Human Brain Mapping, Scientific Reports, Journal of Neuroscience Research).

Scientific Highlights

1. Coelho A, Magalhães R, Moreira PS, Amorim L, Portugal-Nunes C, Castanho T, Santos NC, Sousa N, Fernandes HM (in press). A novel method for estimating connectivity-based parcellation of the human brain from diffusion MRI: application to an aging cohort. Human Brain Mapping. doi: 10.1002/hbm.25773
2. Coelho A, Fernandes HM, Magalhaes R, Moreira PS, Marques P, Soares JM, Amorim L, Portugal-Nunes C, Castanho T, Santos NC, Sousa N (2021) Signatures of white-matter microstructure degradation during aging and its association with cognitive status. Sci Rep, 11(1), 4517. doi: 10.1038/s41598-021-83983-7
3. Coelho A, Fernandes HM, Magalhaes R, Moreira PS, Marques P, Soares JM, Amorim L, Portugal-Nunes C, Castanho T, Santos NC, Sousa N (2021) Reorganization of brain structural networks in aging: A longitudinal study. J Neurosci Res, 99(5), 1354-1376. doi: 10.1002/jnr.24795


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