Andreia Pereira-Nunes

  • CD147
  • GLUD1
  • Cancer
  • Immune system
  • Macrophages
  • Cell metabolism
  • Immunosurveillance
  • Immunotherapy

Andreia Pereira-Nunes (AP-N) is a PhD student in Health Sciences and Biomedical Sciences at the University of Minho and KU Leuven (joint-PhD).
She completed her BSc in Biochemistry in 2016 at the School of Sciences and her MSc in Health Sciences in 2018 at the School of Medicine, at the University of Minho.
In 2017, AP-N pursued her master thesis entitled “Targeting cancer cell metabolism using targeted-drug delivery systems”, under the supervision of Dr. Sara Granja and Prof. Fátima Baltazar. In 2019, she was awarded with a PhD fellowship from Foundation of Science and Technology (FCT) for the project “CD147 in cancer immunosurveillance: new tool for T-cell based immunotherapy?”.
Currently, AP-N is working on her PhD thesis entitled “Macrophage metabolic reprogramming as a therapeutic approach for cancer and muscular dystrophy” at the Life and Health Sciences Research Institute (ICVS)/School of Medicine (University of Minho, Braga, Portugal) and at VIB – KU Leuven Center for Cancer Biology (CCB; KU Leuven, Leuven, Belgium) under the supervision of Prof. Fátima Baltazar, Prof. Massimiliano Mazzone and Dr. Sara Granja.
Her research is mainly focused on metabolic re-education of macrophages in the context of cancer and muscular dystrophy to improve the efficacy of immunotherapies and muscle regeneration, respectively. Additionally, her scientific interests rely on oncology, immunology, cell metabolism and therapeutics.

Scientific Highlights

Research Article: Pereira-Nunes, A, Simões-Sousa, S, Pinheiro, C, Miranda-Gonçalves, V, Granja, S, Baltazar, F. “Targeting lactate production and efflux in prostate cancer” (2020), BBA – Molecular Basis of Disease 1866(11): 165894 doi: 10.1016/j.bbadis.2020.165894
Review Article: Santos, N, Pereira-Nunes, A, Baltazar, F, Granja, S. “Lactate as a regulator of cancer Inflammation and immunity” (2019), Immunometabolism 1(2): e190015 doi:10.20900/immunometab20190015
Book Chapter: Pereira-Nunes, A, Julieta, A, Granja, S, Baltazar, F. “Lactate and lactate transporters as key players in the maintenance of Warburg Effect” in “Tumor Microenvironment – The Main Driver of Metabolic Adaptation” (2020), Springer Nature 1219 doi: 10.1007/978-3-030-34025-4