Lactate metabolism and signalling in cancer
Reprogramming of energy metabolism is a key hallmark of cancer. Most cancer cells undergo the Warburg effect, with enhanced glycolytic metabolism and lactate production, which provides…
- Research
- Cancer Biomarkers and Therapeutics
- Andreia Pereira-Nunes
Andreia Pereira-Nunes
- CD147
- GLUD1
- Muscular dystrophy
- Macrophages
- Cancer Cell metabolism
- Cancer Immune system
Andreia Pereira-Nunes (AP-N) graduated in Biochemistry and holds a master’s degree in Health Sciences from the University of Minho (Braga, Portugal). During her MSc studies, AP-N contributed to the development and characterization of a novel therapeutic tool based on nanosystems to specifically target both glycolysis and OXPHOS pathways in the context of lung cancer.
In 2019, she was awarded a research fellowship from the Foundation of Science and Technology (FCT) and joined the doctoral program in Health Sciences at the Life and Health Sciences Research Institute (ICVS) of the University of Minho.
Her PhD research is centered on the study of potential therapeutic targets for cancer, namely CD147 and GLUD1, with a particular focus on their role in the modulation of tumor cell metabolism and anti-tumor immunity. In addition to research in the Cancer Biomarkers and Therapeutics Team during her PhD course, AP-N also went on a research abroad program at the Laboratory of Tumor Inflammation and Angiogenesis, integrated into the Center for Cancer Biology at VIB-KU Leuven (Belgium), where she also had the opportunity to explore metabolic targets in Duchenne Muscular Dystrophy.
Andreia Pereira-Nunes
- CD147
- GLUD1
- Muscular dystrophy
- Macrophages
- Cancer Cell metabolism
- Cancer Immune system
Andreia Pereira-Nunes (AP-N) graduated in Biochemistry and holds a master’s degree in Health Sciences from the University of Minho (Braga, Portugal). During her MSc studies, AP-N contributed to the development and characterization of a novel therapeutic tool based on nanosystems to specifically target both glycolysis and OXPHOS pathways in the context of lung cancer.
In 2019, she was awarded a research fellowship from the Foundation of Science and Technology (FCT) and joined the doctoral program in Health Sciences at the Life and Health Sciences Research Institute (ICVS) of the University of Minho.
Her PhD research is centered on the study of potential therapeutic targets for cancer, namely CD147 and GLUD1, with a particular focus on their role in the modulation of tumor cell metabolism and anti-tumor immunity. In addition to research in the Cancer Biomarkers and Therapeutics Team during her PhD course, AP-N also went on a research abroad program at the Laboratory of Tumor Inflammation and Angiogenesis, integrated into the Center for Cancer Biology at VIB-KU Leuven (Belgium), where she also had the opportunity to explore metabolic targets in Duchenne Muscular Dystrophy.
Scientific Highlights
Research Articles:
Pereira-Nunes, A; Ferreira, H; Abreu, S; Guedes, M; Neves, N M; Baltazar, F; Granja, S. “Combination therapy with CD147-targeted nanoparticles carrying phenformin decreases lung cancer growth” (2023), Advanced Biology 7(7): e2300080 doi: 10.1002/adbi.202300080
Pereira-Nunes, A; Simões-Sousa, S; Pinheiro, C; Miranda-Gonçalves, V; Granja, S; Baltazar, F. “Targeting lactate production and efflux in prostate cancer” (2020), BBA – Molecular Basis of Disease 1866(11): 165894 doi: 10.1016/j.bbadis.2020.165894
Review Article:
Santos, N; Pereira-Nunes, A; Baltazar, F; Granja, S. “Lactate as a regulator of cancer Inflammation and immunity” (2019), Immunometabolism 1(2): e190015 doi: 10.20900/immunometab20190015
Book Chapter:
Pereira-Nunes, A; Julieta, A; Granja, S; Baltazar, F. “Lactate and lactate transporters as key players in the maintenance of Warburg Effect” in “Tumor Microenvironment – The Main Driver of Metabolic Adaptation” (2020), Springer Nature 1219 doi: 10.1007/978-3-030-34025-4
Poster communications:
Ammarah, U; Pereira-Nunes, A; Shang, M; Di Matteo, M; Granja, S; Baltazar, F; Mazzone, M. “Targeting macrophage GLUD1 inhibits metachronous and synchronous metastases”. Recent insights into Immuno-Oncology (2022)
Pereira-Nunes, A; Santos, N; Baltazar, F; Granja, S. “CD147 in cancer immunosurveillance: new tool for T-cell based immunotherapy?”. EACR 2021 Virtual Congress: Innovative Cancer Science (2021)
Pereira-Nunes, A; Santos, N; Baltazar, F; Granja, S. “Lactate transporters as targets to improve immunotherapy”. EACR-AACR-ASPIC 2020 Conference (2020)
Pereira-Nunes, A; Ferreira, H; Neves, N M; Baltazar, F; Granja, S. “Disruption of cancer cell metabolism using targeted-drug delivery systems”. Webinar: Cancer Biology: From Basic to Translational Research (2020), 6TH Annual Meeting of the International Society of Cancer Metabolism (ISCaM, 2019)
Pereira-Nunes, A; Ferreira, H; Neves, N M; Baltazar, F; Granja, S. “Targeting cancer cell metabolism using targeted-drug delivery systems.” Poster communication. 26TH Porto Cancer Meeting (2019), 25TH Porto Cancer Meeting (2018)
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Phone: +351 253 604 967
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Email: icvs.sec@med.uminho.pt
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
GPS: +41° 33′ 47.33″, -8° 24′ 3.39″
Copyright ©2022 ICVS. All Rights Reserved
Copyright ©2022 ICVS. All Rights Reserved
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
GPS: +41° 33′ 47.33″, -8° 24′ 3.39″
Copyright ©2022 ICVS. All Rights Reserved
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
GPS: +41° 33′ 47.33″, -8° 24′ 3.39″