Bruna Ferreira-Lomba

  • Protein Aggregation
  • C. elegans
  • Mus musculus
  • Folding Sensors
  • Machado-Joseph Disease
  • Neurodegenerative Diseases
  • Pharmacological Therapies
  • Proteostasis
  • Serotonergic Drugs
  • Serotonergic Signaling

Bruna Ferreira-Lomba holds a B.Sc. in Applied Biology (2017) and a M.Sc. in Health Sciences (2020) from the University of Minho. Her motivation is to cooperate in the development of a treatment for Neurodegenerative diseases, in order to provide a better quality of life for these patients. Based on this purpose, she is working in neurosciences research at Life and Health Sciences Research Institute (ICVS) of the University of Minho, since 2017. During her bachelor’s degree project, she studied the pharmacological modulation of serotonergic signaling in the motor behavior of the Caenorhabditis elegans (C. elegans) model of Machado-Joseph disease (MJD). In her master’s degree dissertation, she focused on the analysis of the therapeutic modulation of serotonergic signaling in C. elegans models of proteotoxicity, expressing neuronal proteostasis sensor proteins. Currently, she is a Research technitian in the project entitled “Determining the Efficacy of NLX-112 in a Mouse Experimental Model of Cerebellar Ataxia”, financed by the USA Department of Defense. She possesses experience in biochemical techniques and behavior analysis using C. elegans and Mus musculus models. Bruna published 2 peer-reviewed articles (accumulated impact factor = 12.077), contributed to 3 selected oral presentations and 24 conference posters and received 2 best poster awards. She is also interested in Scientific communication, being actively involved in the organization of scientific workshops and events, such as the celebration of Rare Disease Day virtually at ICVS since 2021.

Scientific Highlights

Jalles, A.*, Vieira, C.*, Pereira-Sousa, J., Vilasboas-Campos, D., Mota, A. F., Vasconcelos, S., Ferreira-Lomba, B., Costa, M. D., Da Silva, J. D., Maciel, P., & Teixeira-Castro, A. (2022). Aripiprazole Offsets Mutant ATXN3-Induced Motor Dysfunction by Targeting Dopamine D2 and Serotonin 1A and 2A Receptors in C. elegans. Biomedicines, 10(2), 370.

Pereira-Sousa, J., Ferreira-Lomba, B., Bellver-Sanchis, A., Vilasboas-Campos, D., Fernandes, J. H., Costa, M. D., Varney, M. A., Newman-Tancredi, A., Maciel, P., & Teixeira-Castro, A. (2021). Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease. Neurobiology of disease, 152, 105278.


Serotonin signaling and proteostasis

This project addresses an unmet medical need- the lack of effective treatment for any of the aging-associated neurodegenerative diseases. Due to the worldwide aging of the population, by 2050 it is expected that over 135 million people…

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