Probing the future of triple Artemisinin-based combination therapy um Angola
There is still no cure for HIV infection and the extensive viral genetic diversity represents the one of the biggest obstacles to develop an effective therapy…
- Research
- Pathogen Evolutionary Genomics and Experimental Genetics
- Claudia Fançony
Claudia Fançony
- Malaria
- drug resistance
- Malaria molecular epidemiology
- Public health
- Pharmacogenetics
- Plasmodium falciparum
Cláudia Fançony holds a degree in Applied Biology from the University of Minho and a PhD in Public Health from the Institute of Public Health, University of Porto, Portugal. She is currently a researcher at both the Health Research Center of Angola and the Life and Health Sciences Research Institute (ICVS). Her main research interests focus on antimalarial drug resistance and malaria molecular epidemiology. Cláudia is leading an innovative project that investigates the opposing selective pressures exerted by two antimalarial drugs on a single parasite target, aiming to identify incompatible resistance mechanisms. This strategy seeks to repurpose existing drugs available in Angola by developing new therapeutic combinations based on pharmacogenetic evidence, offering a pragmatic alternative to the lengthy process of developing new antimalarial drugs.
Claudia Fançony
- Malaria
- drug resistance
- Malaria molecular epidemiology
- Public health
- Pharmacogenetics
- Plasmodium falciparum
Cláudia Fançony holds a degree in Applied Biology from the University of Minho and a PhD in Public Health from the Institute of Public Health, University of Porto, Portugal. She is currently a researcher at both the Health Research Center of Angola and the Life and Health Sciences Research Institute (ICVS). Her main research interests focus on antimalarial drug resistance and malaria molecular epidemiology. Cláudia is leading an innovative project that investigates the opposing selective pressures exerted by two antimalarial drugs on a single parasite target, aiming to identify incompatible resistance mechanisms. This strategy seeks to repurpose existing drugs available in Angola by developing new therapeutic combinations based on pharmacogenetic evidence, offering a pragmatic alternative to the lengthy process of developing new antimalarial drugs.
Scientific Highlights
- Fançony C. et al. Artemether–lumefantrine treatment selects Plasmodium falciparum multidrug resistance 1 (pfmdr1) increased copy number among African malaria infections. Infect. Dis. 2025. doi:10.1093/infdis/jiaf155
- Savonius O., de Souza C.F., Fançony C. et al. PCR-confirmed malaria among children presenting with a decreased level of consciousness in Angola: a prospective observational study. J. 2023;22:130. doi:10.1186/s12936-023-04556-9
- Fançony C. et al. Zinc deficiency interacts with intestinal/urogenital parasites in the pathway to anaemia in preschool children, Bengo-Angola. Nutrients 2022;14:1392. doi:10.3390/nu14071392
- Gil J.P., Fançony C. Plasmodium falciparum multidrug resistance proteins (pfMRPs). Pharmacol. 2021;12:759422. doi:10.3389/fphar.2021.759422
- Fançony C. et al. Effectiveness of nutrition and WASH/malaria educational community-based interventions in reducing anaemia in children from Angola. Rep. 2021;11:5603. doi:10.1038/s41598-021-85006-x
- Fançony C. et al. Anaemia in preschool children from Angola: a review of the evidence. Porto Biomed. J. 2020;5:e60. doi:10.1097/j.pbj.0000000000000060
- Fançony C. et al. Iron-deficiency anaemia among 6- to 36-month-old children from northern Angola. BMC Pediatr. 2020;20:298. doi:10.1186/s12887-020-02185-8
- Lemos M., Pedro J.M., Fançony C. et al. Adverse events from preventive chemotherapy in children: Bengo Province, Angola. PLOS ONE 2020;15:e0229247. doi:10.1371/journal.pone.0229247
- Lemos M., Fançony C. et al. Community-based intervention for schistosomiasis and soil-transmitted helminths in Caxito, Angola. Health 2020;12:86–94. doi:10.1093/inthealth/ihz055
- Fançony C. et al. Study protocol: nutrition and WASH/malaria education to reduce anaemia in Bengo. J. Environ. Res. Public Health 2019;16:466. doi:10.3390/ijerph16030466
- Fançony C., Brito M., Gil J.P. Plasmodium falciparum drug resistance in Angola. J. 2016;15:74. doi:10.1186/s12936-016-1122-z
- Moura S., Fançony C. et al. Impact of a training course on malaria microscopy in Angola. J. 2014;13:437. doi:10.1186/1475-2875-13-437
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Projects
As Leader
Projects
As Member
Defining drug resistance pathways in the malaria parasite
Hampering malaria control and elimination efforts is the resilient capacity of the parasite Plasmodium falciparum to develop resistance, including resistance to the presently…
MAL-PREDICT: Malaria Therapeutic Failure Prediction using Machine Learning
This project aims to develop a machine learning model to predict malaria treatment failure at the patient level, enabling more personalized and effective care…
Contact us
Phone: +351 253 604 967
Fax: +351 253 604 809
Email: icvs.sec@med.uminho.pt
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
GPS: +41° 33′ 47.33″, -8° 24′ 3.39″
Copyright ©2025 ICVS. All Rights Reserved. Developed by TCIT
Copyright ©2025 ICVS. All Rights Reserved. Developed by TCIT
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
GPS: +41° 33′ 47.33″, -8° 24′ 3.39″
Copyright ©2025 ICVS. All Rights Reserved
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
GPS: +41° 33′ 47.33″, -8° 24′ 3.39″