Daniela Vilasboas-Campos obtained a M.Sc. in Plant Molecular Biology, Biotechnology and Bioentrepreneurship (2018) at the University of Minho. She has developed her master’s thesis work at the Life and Health Sciences Research Institute (ICVS) dedicated to the evaluation of antioxidant and neuroprotective effects of medicinal plant extracts in C. elegans models of tauopathy and polyglutamine disease. In 2018, she integrated the EXOS3 collaborative research project with the aim of identifying novel disease-modifying genes and pathways of MJD/SCA3 patients, using a whole-exome approach. In 2019, she was awarded an individual PhD fellowship financed by the Portuguese Foundation for Science and Technology (FCT) with a project focusing on chemogenomics screening for novel therapeutic target identification in a C. elegans model of MJD/SCA3. Daniela Vilasboas-Campos is currently an PhD student in Health Sciences, integrated in the Translational Neurogenetics research team, at ICVS, School of Medicine at the University of Minho. The lack of effective therapeutic strategies for MJD/SCA3 motivates her to perform large-scale phenotype-based drug and genetic screenings in C. elegans, aiming at identifying novel molecules and therapeutic targets. Therefore, she established an automated assay to screen for molecules able to act as enhancers of protein-folding and homeostasis capacity. Currently, she is dedicated to testing several therapeutic approaches in collaborations with various pharmaceutical companies, screening libraries of novel and repurposed compounds and identifying genetic modifier pathways that can provide targets for new drug development, offering new therapeutic possibilities for MJD/SCA3 patients. Vilasboas-Campos received 5 awards (one award for Best Oral Presentation) and published a total of 8 scientific articles to date (two as first-author and six as co-author) in international peer-reviewed journals. To date 23 posters (9 as first author) in international scientific conferences. She is also actively involved in science outreach activities.
Daniela Vilasboas-Campos obtained a M.Sc. in Plant Molecular Biology, Biotechnology and Bioentrepreneurship (2018) at the University of Minho. She has developed her master’s thesis work at the Life and Health Sciences Research Institute (ICVS) dedicated to the evaluation of antioxidant and neuroprotective effects of medicinal plant extracts in C. elegans models of tauopathy and polyglutamine disease. In 2018, she integrated the EXOS3 collaborative research project with the aim of identifying novel disease-modifying genes and pathways of MJD/SCA3 patients, using a whole-exome approach. In 2019, she was awarded an individual PhD fellowship financed by the Portuguese Foundation for Science and Technology (FCT) with a project focusing on chemogenomics screening for novel therapeutic target identification in a C. elegans model of MJD/SCA3. Daniela Vilasboas-Campos is currently an PhD student in Health Sciences, integrated in the Translational Neurogenetics research team, at ICVS, School of Medicine at the University of Minho. The lack of effective therapeutic strategies for MJD/SCA3 motivates her to perform large-scale phenotype-based drug and genetic screenings in C. elegans, aiming at identifying novel molecules and therapeutic targets. Therefore, she established an automated assay to screen for molecules able to act as enhancers of protein-folding and homeostasis capacity. Currently, she is dedicated to testing several therapeutic approaches in collaborations with various pharmaceutical companies, screening libraries of novel and repurposed compounds and identifying genetic modifier pathways that can provide targets for new drug development, offering new therapeutic possibilities for MJD/SCA3 patients. Vilasboas-Campos received 5 awards (one award for Best Oral Presentation) and published a total of 8 scientific articles to date (two as first-author and six as co-author) in international peer-reviewed journals. To date 23 posters (9 as first author) in international scientific conferences. She is also actively involved in science outreach activities.
Articles
Vilasboas-Campos, D., Costa, M. D., Teixeira-Castro, A., Rios, R., Silva, F. G., Bessa, C., Dias, A. C. P., & Maciel, P. (2021). Neurotherapeutic effect of Hyptis spp. leaf extracts in Caenorhabditis elegans models of tauopathy and polyglutamine disease: Role of the glutathione redox cycle. Free Radical Biology & Medicine, 162, 202–215. https://doi.org/10.1016/j.freeradbiomed.2020.10.018
Vilasboas-Campos, D., Costa, M. D., Teixeira-Castro, A., Rios, R., Silva, F. G., Aierken, A., Zhang, X., Bessa, C., Dias, A. C. P., & Maciel, P. (2020). Data on the effects of Hyptis spp. and Lycium spp. plant extracts in C. elegans models of genetically determined neurodegenerative diseases. Data in Brief, 33, 106598. https://doi.org/10.1016/j.dib.2020.106598
Raposo, M., Bettencourt, C., Melo, A. R. V., Ferreira, A. F., Alonso, I., Silva, P., Vasconcelos, J., Kay, T., Saraiva-Pereira, M. L., Costa, M. D., Vilasboas-Campos, D., Bettencourt, B. F., Bruges-Armas, J., Houlden, H., Heutink, P., Jardim, L. B., Sequeiros, J., Maciel, P., & Lima, M. (2022). Novel Machado-Joseph disease-modifying genes and pathways identified by whole-exome sequencing. Neurobiology of Disease, 162, 105578. https://doi.org/10.1016/j.nbd.2021.105578
Jalles, A.*, Vieira, C.*, Pereira-Sousa, J., Vilasboas-Campos, D., Mota, A. F., Vasconcelos, S., Ferreira-Lomba, B., Costa, M. D., Da Silva, J. D., Maciel, P., & Teixeira-Castro, A. (2022). Aripiprazole Offsets Mutant ATXN3-Induced Motor Dysfunction by Targeting Dopamine D2 and Serotonin 1A and 2A Receptors in C. elegans. Biomedicines, 10(2), 370. https://doi.org/10.3390/biomedicines10020370
Pereira-Sousa, J., Ferreira-Lomba, B., Bellver-Sanchis, A., Vilasboas-Campos, D., Fernandes, J. H., Costa, M. D., Varney, M. A., Newman-Tancredi, A., Maciel, P., & Teixeira-Castro, A. (2021). Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease. Neurobiology of Disease, 152, 105278. https://doi.org/10.1016/j.nbd.2021.105278
Duarte-Silva, S.*, Da Silva, J. D.*, Monteiro-Fernandes, D.*, Costa, M. D., Neves-Carvalho, A., Raposo, M., Soares-Cunha, C., Correia, J. S., Nogueira-Goncalves, G., Fernandes, H. S., Oliveira, S., Ferreira-Fernandes, A. R., Rodrigues, F., Pereira-Sousa, J., Vilasboas-Campos, D., Guerreiro, S., Campos, J., Meireles-Costa, L., Rodrigues, C. M. P., Cabantous, S., Sousa, S. F., Lima, M., Teixeira-Castro, A., & Maciel, P. (2024). Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of spinocerebellar ataxia type 3. The Journal of Clinical Investigation, 134(5), e162246. https://doi.org/10.1172/JCI162246
Figueiredo, F., Sárkány, Z., Silva, A., Vilasboas-Campos, D., Maciel, P., Teixeira-Castro, A., Martins, P. M., & Macedo-Ribeiro, S. (2023). Drug repurposing of dopaminergic drugs to inhibit ataxin-3 aggregation. Biomedicine & Pharmacotherapy, 165, 115258. https://doi.org/10.1016/j.biopha.2023.115258
Teixeira-Castro, A., Sousa, J. C., Vieira, C., Pereira-Sousa, J., Vilasboas-Campos, D., Marques, F., Pinto-do-Ó, P., & Maciel, P. (2023). Learning the Biochemical Basis of Axonal Guidance: Using Caenorhabditis elegans as a Model. Biomedicines, 11(6), 1731. https://doi.org/10.3390/biomedicines11061731
Departing from previous work in which we developped cellular and animal models of Machado-Joseph disease, a neurodegenerative disorder caused by expansion of a polyglutamine tract in the protein ataxin-3 (ATXN3)…
This project addresses an unmet medical need- the lack of effective treatment for any of the aging-associated neurodegenerative diseases. Due to the worldwide aging of the population, by 2050 it is expected that over 135 million people…
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Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
Copyright ©2022 ICVS. All Rights Reserved
Copyright ©2022 ICVS. All Rights Reserved
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
Copyright ©2022 ICVS. All Rights Reserved
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
