Ioannis Sotiropoulos

stress
Tau
Abeta
Alzheimer's disease
depression
exosomes
biomarkers

Ioannis Sotiropoulos has graduated form the Biology Department, Patras University (Greece) and he performed an internship at the Columbia University, NY (USA). He obtained a PhD in Neurosciences at Heidelberg Univeristy/Max Planck Institute of Psychiatry (Germany) while we also received traning at Physiology Department, Unniveristy College London (UK). During his postdoc studies, he workjed at RIKEN Brain Science Institute, Tokyo (Japan) and MRC Center for Synaptic Plasiticty, Univeristy of Bristol (UK). He is an affiliated Researcher at ICVS Instiute. His research work focuses on understanding the orchestrating role of environmental risk factors (e.g., chronic stress) on the onset of Alzheimer´s disease (AD) with a specific focus on the relationship between AD and depression, a stress-related disorder. Combining cell-, animal- and human-based studies, Dr. Sotiropoulos’ innovative work aims to clarify the diverse factors that regulate the cellular role of Tau as a key molecule of neuroplasticity and neuropathology in brain pathology. His scientific achievements are internationally recognized in the form of prizes & awards e.g., Hirnliga Alzheimer Award 2009, AD/PD Young Faculty 2014 Award, Jerome Lejeune 2017 Award, Janssen Innovation Award 2017, International Alzheimer Association Best Mentor in Nueroscience Award 2021.

Ioannis Sotiropoulos

stress
Tau
Abeta
Alzheimer's disease
depression
exosomes
biomarkers

Scientific Highlights

1. Alzheimer Association Best Mentor award in Neuroscience 2021;

2. Foundation Jerome Lejeune Research grant 2017;

3. Janssen Prize 2016 for the best Basic Research;

4. Scientific board member the European College of Neuropsychopharmacology (ECNP);

5.Publication: Guerreiro S, Guimarães M, Silva JM, Dioli D, Vamvaka-Iakovou A, Gomes P, Megalokonomou A, Campos-Marques C, Sousa N, Leite-Almeida H, Sotiropoulos I* “Chronic pain causes Tau-dependent hippocampal pathology and memory deficits” Mol Psychiatry 2022 in press;

6. Publicaiton: Dioli C, Patrício P, Pinto LG, Marie C, Morais M, Vyas S, Bessa JM, Pinto L, Sotiropoulos I* “Adult neurogenic process in the subventricular zone-olfactory bulb system is regulated by Tau protein under prolonged stress.” Cell Prolif. 2021 54(7):e13027. https://doi.org/10.1111/cpr.13027

7. Publication: Zhuravleva V, Vaz-Silva J, Zhu M, Gomes P, Silva JM, Sousa N, Sotiropoulos I, Waites CL. “Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβ production.” Cell Death Dis. 2021 12(12):1137. https://doi.org/10.1038/s41419-021-04433-w

8. Publication: Monteiro-Fernandes D, Silva JM, Soares-Cunha C, Dalla C, Kokras N, François A, Billiras R, Bretin S, Sousa N, Sotiropoulos I* “Allosteric modulation of AMPA receptors counteracts Tau-related excitotoxic synaptic signaling and memory deficits in Stress and Aβ-evoked hippocampal pathology” Molecular Psychiatry 2020 May 28. https://doi.org/10.1038/s41380-020-0794-5

Add Your Heading Text Here

Projects

As Leader

Ioannis Sotiropoulos

Chronic Stress as the connecting parameter between stress-related depression & Alzheimer’s disease

Although cumulative evidence suggests a continuum between depression and AD, and stress is suggested to play a detrimental role in both diseases…

Ioannis Sotiropoulos

Understanding the role of chronic stress as a risk factor for Alzheimer’s disease

Alzheimer’s disease (AD), the leading cause of dementia, affects nearly 44 million people worldwide and costs over $600 billion/year (1% of the world’s GDP)…

Ioannis Sotiropoulos

Unrevealing the multifacial role of Tau protein in the adult brain homeostasis beyond Alzheimer’s disease

While Tau protein is originally described as a mainly axonal, microtubule-associated protein, accumulating evidence supports the multiple roles of Tau in different cell…

As Member

Luisa Pinto

Modulation of adult brain cytogenesis for treatment of neuropsychiatric and neurodegenerative diseases

The adult mammalian brain harbors different forms of neural plasticity, ranging from neuronal synapto-dendritic rearrangements to the generation of new neuronal…