Joana Sofia Correia

  • Neuropsychiatry
  • Neurodegeneration
  • Machado-Joseph Disease
  • Ataxin-3
  • Stress
  • Animal models
  • Animal Behavior
  • Preclinical trials

Joana Sofia Correia obtained a B.Sc. in Biochemistry at the University of Porto (2011), and a M.Sc. in Health Sciences at the University of Minho (2014). Throughout her academic career she has worked in the Neurosciences field in translational research projects of neuropsychiatric and neurodegenerative disorders. She has dedicated her master’s thesis to the study of astrocytic neuroprotective functions in a rodent model of depression and afterwards worked as a research technician at the Bn’ML – Behavior and Molecular Lab at Life and Health Sciences Research Institute (ICVS), University of Minho. Later, as a research fellow funded by the National Ataxia Foundation (USA), she has developed work using stem cell-based therapies in the context of Machado-Joseph disease, in the team of Prof. Patrícia Maciel at the ICVS, University of Minho. Currently, she is a PhD student, interested in understanding the modulation of HPA-related stress response in a mouse model of Machado-Joseph disease, and performing biomarker research for therapeutic development. Joana has received 3 awards and published 14 original articles. Since 2021, she is also actively involved in the organization of scientific workshops and events, such as the celebration of Rare Disease Day, virtually and at ICVS.

Scientific Highlights

Correia, J. S., Duarte-Silva, S., Salgado, A. J., & Maciel, P. (2023). Cell-based therapeutic strategies for treatment of spinocerebellar ataxias: an update. Neural regeneration research, 18(6), 1203–1212.

Machado-Santos, A. R., Loureiro-Campos, E., Patrício, P., Araújo, B., Alves, N. D., Mateus-Pinheiro, A., Correia, J. S., Morais, M., Bessa, J. M., Sousa, N., Rodrigues, A. J., Oliveira, J. F., & Pinto, L. (2022). Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure. Cells, 11(3), 390.

Silveira-Rosa, T., Mateus-Pinheiro, A., Correia, J. S., Silva, J. M., Martins-Macedo, J., Araújo, B., Machado-Santos, A. R., Alves, N. D., Silva, M., Loureiro-Campos, E., Sotiropoulos, I., Bessa, J. M., Rodrigues, A. J., Sousa, N., Patrício, P., & Pinto, L. (2022). Suppression of adult cytogenesis in the rat brain leads to sex-differentiated disruption of the HPA axis activity. Cell Proliferation, 55(2), e13165.

Correia, J. S., Neves-Carvalho, A., Mendes-Pinheiro, B., Pires, J., Teixeira, F. G., Lima, R., Monteiro, S., Silva, N. A., Soares-Cunha, C., Serra, S. C., Duarte-Silva, S., Teixeira-Castro, A., Salgado, A. J., & Maciel, P. (2021). Preclinical Assessment of Mesenchymal-Stem-Cell-Based Therapies in Spinocerebellar Ataxia Type 3. Biomedicines, 9(12), 1754.

Patrício, P., Mateus-Pinheiro, A., Machado-Santos, A. R., Alves, N. D., Correia, J. S., Morais, M., Bessa, J. M., Rodrigues, A. J., Sousa, N., & Pinto, L. (2021). Cell Cycle Regulation of Hippocampal Progenitor Cells in Experimental Models of Depression and after Treatment with Fluoxetine. International Journal of Molecular Sciences, 22(21), 11798.

Mateus-Pinheiro, A., Patrício, P., Alves, N. D., Martins-Macedo, J., Caetano, I., Silveira-Rosa, T., Araújo, B., Mateus-Pinheiro, M., Silva-Correia, J., Sardinha, V. M., Loureiro-Campos, E., Rodrigues, A. J., Oliveira, J. F., Bessa, J. M., Sousa, N., & Pinto, L. (2021). Hippocampal cytogenesis abrogation impairs inter-regional communication between the hippocampus and prefrontal cortex and promotes the time-dependent manifestation of emotional and cognitive deficits. Molecular Psychiatry, 26(12), 7154–7166.

Machado-Santos, A. R., Alves, N. D., Araújo, B., Correia, J. S., Patrício, P., Mateus-Pinheiro, A., Loureiro-Campos, E., Bessa, J. M., Sousa, N., & Pinto, L. (2021). Astrocytic plasticity at the dorsal dentate gyrus on an animal model of recurrent depression. Neuroscience, 454, 94–104.

Alves, N. D., Patrício, P., Correia, J. S., Mateus-Pinheiro, A., Machado-Santos, A. R., Loureiro-Campos, E., Morais, M., Bessa, J. M., Sousa, N., & Pinto, L. (2018). Chronic stress targets adult neurogenesis preferentially in the suprapyramidal blade of the rat dorsal dentate gyrus. Brain structure & function, 223(1), 415–428.

Sardinha, V. M., Guerra-Gomes, S., Caetano, I., Tavares, G., Martins, M., Reis, J. S., Correia, J. S., Teixeira-Castro, A., Pinto, L., Sousa, N., & Oliveira, J. F. (2017). Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function. Glia, 65(12), 1944–1960.

Morais, M., Patrício, P., Mateus-Pinheiro, A., Alves, N. D., Machado-Santos, A. R., Correia, J. S., Pereira, J., Pinto, L., Sousa, N., & Bessa, J. M. (2017). The modulation of adult neuroplasticity is involved in the mood-improving actions of atypical antipsychotics in an animal model of depression. Translational Psychiatry, 7(6), e1146.