João Vaz Silva

  • Alzheimer's Disease
  • Pathology
  • Intracellular trafficking
  • Endosomes
  • Exosomes
  • Rab35
  • Tau
  • APP

João Vaz Silva (MD, PhD) graduated in Medicine at the School of Medicine – University of Minho (EM-UM). He obtained a PhD in Medicine in a joint program between EM-UM and Columbia University (USA). Currently, he is a Pathology Resident at IPO-Porto, an invited Assistant Professor at the EM-UM and also an affiliated Researcher at ICVS Institute.
His research work is focused on the influence of intracellular trafficking dynamics on the pathophysiology of Alzheimer’s disease (AD), namely Amyloid Precursor Protein (APP) misprocessing and Tau hyperphophorylation and accumulation, and comprehend the impact of AD risk factors, such as chronic stress/glucocorticoids and ageing, on these intracellular pathways. He aims to develop clinical translational work to study prognostic and staging potential of these membrane trafficking pathways and its by-products. His research work has been published in high-impact research journals.

Scientific Highlights

1. Vaz-Silva J, Gomes P, Jin Q, Zhu M, Zhuravleva V, Quintremil S, Meira T, Silva J, Soares-Cunha C, Daskalakis N, Sousa N, Sotiropoulos I, Waites CL (2018) Endolysosomal degradation of Tau and its role in glucocorticoid‐driven hippocampal malfunction. The EMBO Journal 10.15252/embj.201899084
2. Vaz-Silva J*, Zhuravleva V*, Zhu M, Gomes P, Silva JM, Sousa N, Sotiropoulos I, Waites CL (2021). “Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβ production”, Cell Death and Disease
3. Lopes S, Vaz-Silva J, Pinto V, Dalla C, Kokras N, Bedenk B, Mack N, Czisch M, Almedia OFX, Sousa N, Sotiropoulos I (2016) Tau protein is essential for stress-induced brain pathology. PNAS USA 10.1073/pnas.1600953113
4. Lopes S, Tetlytska L, Vaz-Silva J, Dioli C, Trindade R, Morais M, Webhofer C, Almeida OFX, Turck C, Sousa N, Sotiropoulos I*, Filiou MD* (2016) Tau depletion prevents stress-induced dendritic atrophy in prefontal cortex: role of synaptic mitochondria. Cerebr Cortex 10.1093/cercor/bhw057
5. Pinheiro S, Silva J, Mota C, Vaz-Silva J, Veloso A, Pinto V, Sotiropoulos I (2015) Tau mislocation in glucocorticoid-triggered hippocampal pathology. Mol Neurobiol 10.1007/s12035-015-9356-2
6. Dunn M, Boltaev U, Beskow A, Pampou S, Realubit R, Meira T, Silva JV, Reeb R, Karan C, Jockusch S, Sulzer D, Chang YT, Sames D, Waites CL (2017) Identification of Fluorescent Small Molecule Compounds for Synaptic Labeling by Image-Based, High-Content Screening. ACS Chem Neurosci. 10.1021/acschemneuro.7b00263.
1. Awarded a PhD Scholarship by the Portuguese Foundation for Science and Technology (FCT) (2014)
2. Awarded a scholarship for Research Clerkship at Harvard Medical School (USA) – Department of Biological Chemistry & Molecular Pharmacology granted by Luso-American Foundation (2012)
3. “Janssen Innovation Prize – Portugal” (2016) for the development of research excellence – Winning Team