Jorge H. Fernandes obtained a B.SC. in Biochemistry (2018) and a M. Sc. In Applied Biochemistry with a specialization in Biomedicine (2021) at University of Minho, having developed is dissertation work at the Life and Health Sciences Research Institute (ICVS), under the supervision of Prof. Patrícia Maciel. During this time, he focused on understanding the potential of natural products originated from Chinese medicinal plants as therapies for neurodegenerative diseases, using C. elegans models.
During his Master dissertation work he was involved in the study of the 5-HT 1A serotonin receptor as a novel therapeutic target in a Machado-Joseph disease C. elegans model, being author of one peer reviewed paper.
Jorge is currently a Ph.D. student at the ICVS in the School of Medicine, University of Minho. His work focuses on the role of autophagy as an intracellular food sensing mechanism with impact of behaviour modulation, making use of the C. elegans model.
Jorge H. Fernandes obtained a B.SC. in Biochemistry (2018) and a M. Sc. In Applied Biochemistry with a specialization in Biomedicine (2021) at University of Minho, having developed is dissertation work at the Life and Health Sciences Research Institute (ICVS), under the supervision of Prof. Patrícia Maciel. During this time, he focused on understanding the potential of natural products originated from Chinese medicinal plants as therapies for neurodegenerative diseases, using C. elegans models.
During his Master dissertation work he was involved in the study of the 5-HT 1A serotonin receptor as a novel therapeutic target in a Machado-Joseph disease C. elegans model, being author of one peer reviewed paper.
Jorge is currently a Ph.D. student at the ICVS in the School of Medicine, University of Minho. His work focuses on the role of autophagy as an intracellular food sensing mechanism with impact of behaviour modulation, making use of the C. elegans model.
Articles
Costa, M. D., Da Silva, J. D., Almeida, D., Pereira-Sousa, J., Vilasboas-Campos, D., Fernandes, J. H., Teixeira-Castro, A., & Maciel, P. (2025). Differential effects of lifespan-extending genetic manipulations in an animal model of MJD/SCA3. Mechanisms of ageing and development, 225, 112064. https://doi.org/10.1016/j.mad.2025.112064 ; Fernandes, J. H., Costa, M. D., Vilasboas-Campos, D., Ferreira-Lomba, B., Pereira-Sousa, J., Wang, Q., Teixeira-Castro, A., Liu, X., Wang, F., Dias, A. C. P., & Maciel, P. (2025). Therapeutic Effects of Hemerocallis citrina Baroni Extract on Animal Models of Neurodegenerative Diseases Through Serotonin and HLH-30/TFEB-Dependent Mechanisms. International journal of molecular sciences, 26(9), 4145. https://doi.org/10.3390/ijms26094145
Pereira-Sousa, J., Ferreira-Lomba, B., Bellver-Sanchis, A., Vilasboas-Campos, D., Fernandes, J. H., Costa, M. D., Varney, M. A., Newman-Tancredi, A., Maciel, P., & Teixeira-Castro, A. (2021). Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease. Neurobiology of disease, 152, 105278. https://doi.org/10.1016/j.nbd.2021.105278
Departing from previous work in which we developped cellular and animal models of Machado-Joseph disease, a neurodegenerative disorder caused by expansion of a polyglutamine tract in the protein ataxin-3 (ATXN3)…
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Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
Copyright ©2025 ICVS. All Rights Reserved. Developed by TCIT
Copyright ©2025 ICVS. All Rights Reserved. Developed by TCIT
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
Copyright ©2025 ICVS. All Rights Reserved
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
