Jorge H. Fernandes

  • C. elegans
  • Autophagy
  • Feeding behaviour
  • Natural products
  • Neurodegenerative diseases

Jorge H. Fernandes obtained a B.SC. in Biochemistry (2018) and a M. Sc. In Applied Biochemistry with a specialization in Biomedicine (2021) at University of Minho, having developed is dissertation work at the Life and Health Sciences Research Institute (ICVS), under the supervision of Prof. Patrícia Maciel. During this time, he focused on understanding the potential of natural products originated from Chinese medicinal plants as therapies for neurodegenerative diseases, using C. elegans models.
During his Master dissertation work he was involved in the study of the 5-HT 1A serotonin receptor as a novel therapeutic target in a Machado-Joseph disease C. elegans model, being author of one peer reviewed paper.
Jorge is currently a Ph.D. student at the ICVS in the School of Medicine, University of Minho. His work focuses on the role of autophagy as an intracellular food sensing mechanism with impact of behaviour modulation, making use of the C. elegans model.

Scientific Highlights

Pereira-Sousa, J., Ferreira-Lomba, B., Bellver-Sanchis, A., Vilasboas-Campos, D., Fernandes, J. H., Costa, M. D., Varney, M. A., Newman-Tancredi, A., Maciel, P., & Teixeira-Castro, A. (2021). Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease. Neurobiology of disease, 152, 105278.