Scientific Highlights
Articles
Duarte-Silva, S.*, Da Silva, J. D.*, Monteiro-Fernandes, D.*, Costa, M. D., Neves-Carvalho, A., Raposo, M., Soares-Cunha, C., Correia, J. S., Nogueira-Goncalves, G., Fernandes, H. S., Oliveira, S., Ferreira-Fernandes, A. R., Rodrigues, F., Pereira-Sousa, J., Vilasboas-Campos, D., Guerreiro, S., Campos, J., Meireles-Costa, L., Rodrigues, C. M. P., Cabantous, S., Sousa, S. F., Lima, M., Teixeira-Castro, A., & Maciel, P. (2024). Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of spinocerebellar ataxia type 3. The Journal of Clinical Investigation, 134(5), e162246. https://doi.org/10.1172/JCI162246
Costa, M. D., & Maciel, P. (2022). Modifier pathways in polyglutamine (PolyQ) diseases: from genetic screens to drug targets. Cellular and molecular life sciences : CMLS, 79(5), 274. https://doi.org/10.1007/s00018-022-04280-8
Da Silva, J. D., Oliveira, S., Pereira-Sousa, J., Teixeira-Castro, A., Costa, M. D., & Maciel, P. (2020). Loss of egli-1, the Caenorhabditis elegans Orthologue of a Downstream Target of SMN, Leads to Abnormalities in Sensorimotor Integration. Molecular neurobiology, 57(3), 1553–1569. https://doi.org/10.1007/s12035-019-01833-0
Jalles, A.*, Vieira, C.*, Pereira-Sousa, J., Vilasboas-Campos, D., Mota, A. F., Vasconcelos, S., Ferreira-Lomba, B., Costa, M. D., Da Silva, J. D., Maciel, P., & Teixeira-Castro, A. (2022). Aripiprazole Offsets Mutant ATXN3-Induced Motor Dysfunction by Targeting Dopamine D2 and Serotonin 1A and 2A Receptors in C. elegans. Biomedicines, 10(2), 370. https://doi.org/10.3390/biomedicines10020370
Oliveira-Pinto, S., Pontes, O., Lopes, D., Sampaio-Marques, B., Costa, M. D., Carvalho, L., Gonçalves, C. S., Costa, B. M., Maciel, P., Ludovico, P., Baltazar, F., Proença, F., & Costa, M. (2020). Unravelling the anticancer potential of functionalized chromeno[2,3-b]pyridines for breast cancer treatment. Bioorganic chemistry, 100, 103942. https://doi.org/10.1016/j.bioorg.2020.103942
Pereira-Sousa, J., Ferreira-Lomba, B., Bellver-Sanchis, A., Vilasboas-Campos, D., Fernandes, J. H., Costa, M. D., Varney, M. A., Newman-Tancredi, A., Maciel, P., & Teixeira-Castro, A. (2021). Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease. Neurobiology of disease, 152, 105278. https://doi.org/10.1016/j.nbd.2021.105278
Pohl, F., Teixeira-Castro, A., Costa, M. D., Lindsay, V., Fiúza-Fernandes, J., Goua, M., Bermano, G., Russell, W., Maciel, P., & Kong Thoo Lin, P. (2019). GST-4-Dependent Suppression of Neurodegeneration in C. elegans Models of Parkinson’s and Machado-Joseph Disease by Rapeseed Pomace Extract Supplementation. Frontiers in neuroscience, 13, 1091. https://doi.org/10.3389/fnins.2019.01091
Vilasboas-Campos, D., Costa, M. D., Teixeira-Castro, A., Rios, R., Silva, F. G., Aierken, A., Zhang, X., Bessa, C., Dias, A. C. P., & Maciel, P. (2020). Data on the effects of Hyptis spp. and Lycium spp. plant extracts in C. elegans models of genetically determined neurodegenerative diseases. Data in brief, 33, 106598. https://doi.org/10.1016/j.dib.2020.106598
Vilasboas-Campos, D., Costa, M. D., Teixeira-Castro, A., Rios, R., Silva, F. G., Bessa, C., Dias, A. C. P., & Maciel, P. (2021). Neurotherapeutic effect of Hyptis spp. leaf extracts in Caenorhabditis elegans models of tauopathy and polyglutamine disease: Role of the glutathione redox cycle. Free radical biology & medicine, 162, 202–215. https://doi.org/10.1016/j.freeradbiomed.2020.10.018
Funding and Awards
Seed money research award (2019-2020), National Ataxia Foundation (USA): Genetic screening for identification of novel therapeutic targets in SCA3