Nadine C. Santos

  • ageing
  • neuropsychology
  • neurocognition
  • mood
  • physical activity
  • dietary habits
  • population-based studies

Nadine C Santos, PhD, currently holds a researcher position at the Association P5 Digital Medical Centre (Centro Medicina Digital P5, ACMP5), and was previously a post-doctoral researcher at the Clinical Academic Center-Braga (2CA-B) and a research assistant at the School of Medicine (EM), Life and Health Sciences Research Institute (ICVS), University of Minho (UMinho; Braga, Portugal) and ICVS/3B’s – PT Government Associate Laboratory (Braga/Guimarães, Portugal). Is an Invited Assistant Professor at the School of Medicine of UMinho in the Medical Humanities area. The continued research goal of her work is to explore variables contributing to homeostasis and healthy brain ageing, as assessed by cognitive performance (potential, preservation and limits) and mood state. Multidisciplinary approaches (neuropsychological/ assessment and endocrine and metabolic physiology) are applied in a cross-sectional and longitudinal fashion in population-based cohorts. Is a member of the Life and Health Sciences Ethics Committee of UMinho. Has supervised 4 doctoral students who have completed their PhD degree, and currently supervises 1 other doctoral student, in ageing and delirium-related studies, respectively. Holds a PhD in Molecular Biosciences (School of Molecular Biosciences, Washington State University), a Masters of Forensic Science (Sam Houston State University), and a Bachelor of Arts in Biochemistry (Austin College). Is an Associate Editor at Behavioural Brain Research, a Review Editor at Frontiers in Aging Neuroscience, and an Editorial Board Member at Aging Brain. Has published over 70 peer-reviewed, international papers, with over 900 citations, with a h-index of 18 (Web of Science ResearcherID: K-7431-2015; Orcid:

Scientific Highlights

1. Domingos C, Pêgo JM, Santos NC (2021) Effects of physical activity on brain function and structure in older adults: a systematic review. Behavioural Brain Research 402: 113061. doi: 10.1016/j.bbr.2020.113061
2. Rodrigues B, Asamane E, Magalhães R, Sousa N, Thompson J, Santos NC (2020) The association of dietary patterns with cognition through the lens of neuroimaging—a systematic review. Ageing Research Reviews 63(2020):101145. doi: 10.1016/j.arr.2020.101145
3. Amorim L, Magalhães R, Coelho A, Moreira PS, Portugal-Nunes C, Castanho TC, Marques P, Sousa N, Santos NC (2018) Poor sleep quality associates with decreased functional and structural brain connectivity in normative aging: a MRI multimodal approach. Frontiers in Aging Neuroscience 10:375. doi: 10.3389/fnagi.2018.00375
4. Castanho TC, Sousa N, Santos NC (2017) When new technology is an answer for old problems: the use of videoconferencing in cognitive ageing assessment. Journal of Alzheimer’s Disease Reports 1(1):1-7. doi: 10.3233/ADR-170007
5. Castanho TC, Portugal-Nunes Carlos, Moreira PS, Amorim L, Palha JA, Sousa N, Santos NC (2016) Applicability of the Telephone Interview for Cognitive Status (Modified) in a community sample with low education level: association with an extensive neuropsychological battery. International Journal of Geriatric Psychiatry 31:128-36. doi: 10.1002/gps.4301
6. Santos NC, Costa PS, Cunha P, Portugal-Nunes C, Amorim L, Cotter J, Cerqueira JJ, Palha JA and Sousa N (2014) Clinical, physical and lifestyle indicators and relationship with cognition and mood in ageing: a cross-sectional analysis of distinct educational groups. Frontiers in Aging Neuroscience 6:21. doi: 10.3389/fnagi.2014.00021
7. Santos NC, Costa PS, Cunha P, Cotter J, Sampaio A, Zihl J, Almeida O, Cerqueira JJ, Palha JA, Sousa N (2013) Mood is a key determinant of cognitive performance in community-dwelling older adults: a cross-sectional analysis. Age (Dordr) 35:1983-1993. doi: 10.1007/s11357-012-9482-y
8. Member Life and Health Sciences Ethics Committee (CEICVS) at University of Minho
9. Principal Investigador (PI), “GIRO Project: A digital activity platform for seniors in social isolation” (FCT – Fundação para a Ciência e a Tecnologia (Portugal), Contract grant RESEARCH4COVID 078_596650495)


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