Determinants of neurocognitive function in senior adults: trajectories across time
From an aggregation of multiple population-based team projects, this Project builds on Team achievements, on healthy (cognitive) ageing, across the last decade…
- Research
- Ageing in the Digital Era
- Nuno Sousa
Nuno Sousa
- aging
- stress
- neuroimaging
- digital health
- cognition
Nuno Sousa (MD, PhD) is Full Professor and President of the School of Medicine, University of Minho.Nuno Sousa serves at several medical education and medical assessment advisory boards (NBME, EuroBMA). He is Visiting Professor at Upstate Medical University, NY. He is a NeuroRadiologist. Presently, he is the Director of the Clinical Academic Center at Hospital de Braga and of the Digital Medical Center P5. He is a researcher in the field of Neurosciences at ICVS. His research main interests are focused in the establishment of functional and structural correlations mediated by stress and its implications in neuropsychiatric disorders and in aging. Nuno Sousa coordinates several national and international scientific projects, in the field of neuroscience and digital health. In addition to academic merits, Nuno Sousa serves on several science policy and advisory board positions, and as an Ad hoc reviewer for various neuroscience journal and international funding organizations. He has published more than 500 papers, been cited more than 20000 and has a H-factor of 72. He is one of the 1% most influent researchers according to a recent study in PlosBiology.
Nuno Sousa
- aging
- stress
- neuroimaging
- digital health
- cognition
Nuno Sousa (MD, PhD) is Full Professor and President of the School of Medicine, University of Minho.Nuno Sousa serves at several medical education and medical assessment advisory boards (NBME, EuroBMA). He is Visiting Professor at Upstate Medical University, NY. He is a NeuroRadiologist. Presently, he is the Director of the Clinical Academic Center at Hospital de Braga and of the Digital Medical Center P5. He is a researcher in the field of Neurosciences at ICVS. His research main interests are focused in the establishment of functional and structural correlations mediated by stress and its implications in neuropsychiatric disorders and in aging. Nuno Sousa coordinates several national and international scientific projects, in the field of neuroscience and digital health. In addition to academic merits, Nuno Sousa serves on several science policy and advisory board positions, and as an Ad hoc reviewer for various neuroscience journal and international funding organizations. He has published more than 500 papers, been cited more than 20000 and has a H-factor of 72. He is one of the 1% most influent researchers according to a recent study in PlosBiology.
Scientific Highlights
1. Editor Chief of Frontiers in Behavioral Neuroscience
2. Gold Medal of the Minister of Health, 2011
3. Magalhães R, Picó-Pérez M, Esteves M, Vieira R, Castanho TC, Amorim L, Sousa M, Coelho A, Fernandes HM, Cabral J, Moreira PS, Sousa N. (2021) Habitual coffee drinkers display a distinct pattern of brain functional connectivity. Mol Psychiatry. 2021 Nov;26(11):6589-6598. https://doi.org/10.1038/s41380-021-01075-4
4. Magalhães R, Barrière DA, Novais A, Marques F, Marques P, Cerqueira J, Sousa JC, Cachia A, Boumezbeur F, Bottlaender M, Jay TM, Mériaux S, Sousa N. (2018) The dynamics of stress: a longitudinal MRI study of rat brain structure and connectome. Mol Psychiatry. 23,1998-2006. https://doi.org/10.1038/mp.2017.244
5. Sousa N. (2016) The dynamics of the stress neuromatrix. Molecular Psychiatry 21(3):302-12. https://doi.org/10.1038/mp.2015.196
6. Marques P, Moreira P, Magalhães R, Costa P, Santos N, Zihl J, Soares J, Sousa N. (2016) The functional connectome of cognitive reserve. Hum Brain Mapp. Sep;37(9):3310-22. https://doi.org/10.1002/hbm.23242
7. Dias-Ferreira E, Sousa JC, Melo I, Morgado P, Mesquita AR, Cerqueira JJ, Costa RM, Sousa N. (2009) Chronic stress causes frontostriatal reorganization and affects decision-making. Science, 325:621-5. https://doi.org/10.1126/science.1171203
8. Bessa JM, Ferreira D, Melo I, Marques F, Cerqueira JJ, Palha JA, Almeida OF, Sousa N. (2009) The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling. Molecular Psychiatry 14:764-73. https://doi.org/10.1038/mp.2008.119
9. Cerqueira JJ, Mailliet F, Almeida OF, Jay TM, Sousa N. (2007) The prefrontal cortex as a key target of the maladaptive response to stress. Journal of Neuroscience 27:2781-2787. https://doi.org/10.1523/JNEUROSCI.4372-06.2007
10. Sousa N, Lukoyanov NV, Madeira MD, Almeida OF, Paula-Barbosa MM. (2000) Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement. Neuroscience, 97: 253-266. https://doi.org/10.1016/s0306-4522(00)00050-6
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Projects
As Leader
MINHO Ageing Data Lake: From data to evidence generation
In our Digital Era, it is crucial the establishment of innovative strategies that work to bolster health promotion, studies and/or programs designed to reduce the loss of independence in the older years, and the full utilization of already existing data…
Projects
As Member
A multimodal translational approach to explore the role of neuroplasticity in depression and antidepressant treatment: from the bench to the bedside
Depression is a highly prevalent mood disorder that inflicts a heavy burden in depressed patients and a significant social and economic impact worldwide…
Automating analysis and training in Focused Cardiac Ultrasound (AutoFoCUS)
Focused cardiac ultrasound (FoCUS) refers to the use of ultrasound imaging to evaluate cardiac structure and function at the bedside by a treating physician. In recent years, FoCUS has become an indispensable first-line diagnostic tool, complementing…
Brainstem orchestration of cue-reward associations
The brain constantly integrates new sensory information, and associates environmental cues to outcomes, adjusting behavior to maximize reward and minimize unpleasant consequences. This process is critical for survival, and its dysregulation is a hallmark of…
Creation and implementation of a multidisciplinary digital care consultation for seniors in palliative care
The “P5 Palliative Care” digital multidisciplinary consultation is intended for people over 65 years of age whose illness, being serious and/or incurable, can cause situations of intense suffering for…
Impact of prenatal stress in the brain: from rodents to humans
Early life adversity can have long lasting consequences for the individual, increasing the vulnerability to develop neuropsychiatric disorders later in life…
Modeling and assessing the neurobiological mechanisms of major depressive disorder using preclinical animal models and IPSCs from patients
Depression affects around 16% of the world population and is the leading cause of disability worldwide. This means that around 300 million people are now living with depression…
Modulation of adult brain cytogenesis for treatment of neuropsychiatric and neurodegenerative diseases
The adult mammalian brain harbors different forms of neural plasticity, ranging from neuronal synapto-dendritic rearrangements to the generation of new neuronal…
Neural Circuits of Stigma: Fixed or Flexible
Older persons are subject to stigmatizing attitudes held by the public and even health professionals. At the same time, they themselves hold stigmatzing attitudes towards younger persons as well as their peers…
Contact us
Phone: +351 253 604 967
Fax: +351 253 604 809
Email: icvs.sec@med.uminho.pt
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
GPS: +41° 33′ 47.33″, -8° 24′ 3.39″
Copyright ©2022 ICVS. All Rights Reserved
Copyright ©2022 ICVS. All Rights Reserved
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
GPS: +41° 33′ 47.33″, -8° 24′ 3.39″
Copyright ©2022 ICVS. All Rights Reserved
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
GPS: +41° 33′ 47.33″, -8° 24′ 3.39″