Patrícia Gomes

Stress, EVs
EVs
exosomes
brain
human
tau protein

Patrícia Gomes, MD/PhD student, focus on understanding the role of stress in the pathomechanisms leading to Alzheimer’s disease (AD) and Depression. Her work has unravelled the effect of chronic stress on EVs and exosomes biogenesis as well as the contribution of these vesicles to Tau pathology propagation in the brain. Patrícia Gomes is also interested in human blood-derived biomarkers in exosomes for earlier diagnosis, prognosis and follow-up of these neuropsychiatric disorders.

Patrícia Gomes

Stress, EVs
EVs
exosomes
brain
human
tau protein

Scientific Highlights

1. Novel protocol for brain-derived EV isolation based on their spontaneous release (under patent consideration)
2. Silva JM, Rodrigues S, Marques MB, Gomes P, Neves-Carvalho A, Soares-Cunha C, Takashima A, Ludovico P, Takashima A, Wolozin B, Sousa N, Sotiropoulos I, “Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology”, Cell Death & Differentiation November 2018. (DOI:10.1038/s41418- 018-0217-1 IF=8.339)
3. Vaz-Silva J, Gomes P, Quintremil S, Chu M, Zhuravleva V, Meira T, Silva JM, Dioli C, Soares-Cunha C, Daskalakis NP, Sousa N, Sotiropoulos I, Waites CL, “Endo-lysomal sorting and degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction”, EMBOJ July 2018. (DOI:10.15252/embj.201899084 IF=10.6)
4. Zhuravleva V, Vaz-Silva J, Zhu M, Gomes P, Silva JM, Sousa N, Sotiropoulos I, Waites CL. Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβ production. Cell Death Dis. December 2021 (DOI: 10.1038/s41419- 021-04433-w IF=8.46)
5. Guerreiro S, Guimarães M, Silva J, Dioli C, Sousa R, Gomes P, Campos-Marques C, Cunha A, Almeida A, Sousa N, LeiteAlmeida H, Vamvaka-Iakovou A, Megalokonomou A, Sotiropoulos, I. Chronic pain causes Tau-mediated hippocampal pathology and memory deficits. Mol Psy. [accepted April, 2022]

Add Your Heading Text Here

Projects

As Leader

Projects

As Member

Ioannis Sotiropoulos

Chronic Stress as the connecting parameter between stress-related depression & Alzheimer’s disease

Although cumulative evidence suggests a continuum between depression and AD, and stress is suggested to play a detrimental role in both diseases…

Ioannis Sotiropoulos

Understanding the role of chronic stress as a risk factor for Alzheimer’s disease

Alzheimer’s disease (AD), the leading cause of dementia, affects nearly 44 million people worldwide and costs over $600 billion/year (1% of the world’s GDP)…

Ioannis Sotiropoulos

Unrevealing the multifacial role of Tau protein in the adult brain homeostasis beyond Alzheimer’s disease

While Tau protein is originally described as a mainly axonal, microtubule-associated protein, accumulating evidence supports the multiple roles of Tau in different cell…