Scientific Highlights

1. Novel protocol for brain-derived EV isolation based on their spontaneous release (under patent consideration)
2. Silva JM, Rodrigues S, Marques MB, Gomes P, Neves-Carvalho A, Soares-Cunha C, Takashima A, Ludovico P, Takashima A, Wolozin B, Sousa N, Sotiropoulos I, “Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology”, Cell Death & Differentiation November 2018. (DOI:10.1038/s41418- 018-0217-1 IF=8.339)
3. Vaz-Silva J, Gomes P, Quintremil S, Chu M, Zhuravleva V, Meira T, Silva JM, Dioli C, Soares-Cunha C, Daskalakis NP, Sousa N, Sotiropoulos I, Waites CL, “Endo-lysomal sorting and degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction”, EMBOJ July 2018. (DOI:10.15252/embj.201899084 IF=10.6)
4. Zhuravleva V, Vaz-Silva J, Zhu M, Gomes P, Silva JM, Sousa N, Sotiropoulos I, Waites CL. Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβ production. Cell Death Dis. December 2021 (DOI: 10.1038/s41419- 021-04433-w IF=8.46)
5. Guerreiro S, Guimarães M, Silva J, Dioli C, Sousa R, Gomes P, Campos-Marques C, Cunha A, Almeida A, Sousa N, LeiteAlmeida H, Vamvaka-Iakovou A, Megalokonomou A, Sotiropoulos, I. Chronic pain causes Tau-mediated hippocampal pathology and memory deficits. Mol Psy. [accepted April, 2022]