Patrícia Gomes

  • Stress, EVs
  • EVs
  • exosomes
  • brain
  • human
  • tau protein

Patrícia Gomes, MD/PhD student, focus on understanding the role of stress in the pathomechanisms leading to Alzheimer’s disease (AD) and Depression. Her work has unravelled the effect of chronic stress on EVs and exosomes biogenesis as well as the contribution of these vesicles to Tau pathology propagation in the brain. Patrícia Gomes is also interested in human blood-derived biomarkers in exosomes for earlier diagnosis, prognosis and follow-up of these neuropsychiatric disorders.

Scientific Highlights

1. Novel protocol for brain-derived EV isolation based on their spontaneous release (under patent consideration)
2. Silva JM, Rodrigues S, Marques MB, Gomes P, Neves-Carvalho A, Soares-Cunha C, Takashima A, Ludovico P, Takashima A, Wolozin B, Sousa N, Sotiropoulos I, “Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology”, Cell Death & Differentiation November 2018. (DOI:10.1038/s41418- 018-0217-1 IF=8.339)
3. Vaz-Silva J, Gomes P, Quintremil S, Chu M, Zhuravleva V, Meira T, Silva JM, Dioli C, Soares-Cunha C, Daskalakis NP, Sousa N, Sotiropoulos I, Waites CL, “Endo-lysomal sorting and degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction”, EMBOJ July 2018. (DOI:10.15252/embj.201899084 IF=10.6)
4. Zhuravleva V, Vaz-Silva J, Zhu M, Gomes P, Silva JM, Sousa N, Sotiropoulos I, Waites CL. Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβ production. Cell Death Dis. December 2021 (DOI: 10.1038/s41419- 021-04433-w IF=8.46)
5. Guerreiro S, Guimarães M, Silva J, Dioli C, Sousa R, Gomes P, Campos-Marques C, Cunha A, Almeida A, Sousa N, LeiteAlmeida H, Vamvaka-Iakovou A, Megalokonomou A, Sotiropoulos, I. Chronic pain causes Tau-mediated hippocampal pathology and memory deficits. Mol Psy. [accepted April, 2022]