Scientific Highlights

Yu Q, Du F, Belli I, Gomes PA, Sotiropoulos I, Waites CL. Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain. Cell Death Dis. 2024 Jan 18;15(1):73. (https://doi.org/10.1038/s41419-024-06458-3 IF=9.0)

Gomes PA, Bodo C, Nogueras-Ortiz C, Samiotaki M, Chen M, Soares-Cunha C, Silva JM, Coimbra B, Stamatakis G, Santos L, Panayotou G, Tzouanou F, Waites CL, Gatsogiannis C, Sousa N, Kapogiannis D, Costa-Silva B, Sotiropoulos I. A novel isolation method for spontaneously released extracellular vesicles from brain tissue and its implications for stress-driven brain pathology. Cell Commun Signal. 2023 Feb 13;21(1):35. (https://doi.org/10.1186/s12964-023-01045-z IF=8.4)

Gomes P, Tzouanou F, Skolariki K, Vamvaka-Iakovou A, Noguera-Ortiz C, Tsirtsaki K, Waites CL, Vlamos P, Sousa N, Costa-Silva B, Kapogiannis D, Sotiropoulos I. Extracellular vesicles and Alzheimer’s disease in the novel era of Precision Medicine: implications for disease progression, diagnosis and treatment. Exp Neurol. 2022 Dec;358:114183. (https://doi.org/10.1016/j.expneurol.2022.114183. IF=5.62)

Guerreiro S, Guimarães M, Silva J, Dioli C, Sousa R, Gomes P, Campos-Marques C, Cunha A, Almeida A, Sousa N, Leite-Almeida H, Vamvaka-Iakovou A, Megalokonomou A, Sotiropoulos, I. Chronic pain causes Tau-mediated hippocampal pathology and memory deficits. Mol Psychiatry. 2022 Nov;27(11):4385-4393. (https://doi.org/10.1038/s41380-022-01707-3. Epub 2022 Sep 2. IF=11.9).

Zhuravleva V, Vaz-Silva J, Zhu M, Gomes P, Silva JM, Sousa N, Sotiropoulos I, Waites CL. Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβproduction. Cell Death Dis. December 2021 (https://doi.org/10.1038/s41419-021-04433-w IF=8.46)

Vaz-Silva J, Gomes P, Quintremil S, Chu M, Zhuravleva V, Meira T, Silva JM, Dioli C, Soares-Cunha C, Daskalakis NP, Sousa N, Sotiropoulos I, Waites CL, “Endo-lysomal sorting and degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction”, EMBOJ July 2018. (https://doi.org/10.15252/embj.201899084 IF=10.6)

Silva JM, Rodrigues S, Marques MB, Gomes P, Neves-Carvalho A, Soares-Cunha C, Takashima A, Ludovico P, Takashima A, Wolozin B, Sousa N, Sotiropoulos I, “Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology”, Cell Death & Differentiation November 2018. (https://doi.org/10.1038/s41418-018-0217-1 IF=8.339)