Pedro Morgado
Principal Investigator
Project Leader
Treating refractory obsessive-compulsive disorder using real-time functional magnetic resonance imaging
Obsessive compulsive-disorder (OCD) is a chronic psychiatric illness associated with significant morbidity and dysfunction. The therapeutic response to conventional treatments (pharmacotherapy and cognitive-behavioral therapy) is relatively poor compared with that of other mental disorders. Radio and neurosurgical procedures are reserved for severe, treatment-refractory disease that has not responded to treatments. Identifying alternative and non-invasive treatments is a priority. Although the pathophysiology of OCD is unclear, hyperactivity of orbitofrontal cortex (OFC) has been consistently demonstrated. Neurofeedback with real time functional magnetic resonance has been demonstrated as an effective technique to normalize OFC activity in OCD patients. Thus, we propose to investigate the effectiveness of this therapeutic approach in refractory OCD.
Funding Agency
Clinical Academic Center-Braga (2CA-Braga)
Project Reference
CMIOCD
Project Members
Maria Picó-Pérez
Assistant Researcher
Sónia Ferreira
Clinician-Researcher
Mafalda Machado-Sousa
PhD Student
Main Project Outcomes
S. Queirós, “Right ventricular segmentation in multi-view cardiac MRI using a unified U-net model”, in E. Puyol Antón et al. (eds) Statistical Atlases and Computational Models of the Heart. Multi-Disease, Multi-View, and Multi-Center Right Ventricular Segmentation in Cardiac MRI Challenge. STACOM 2021. Lecture Notes in Computer Science, vol 13131, pp. 287-295, Springer, Cham, 2022.
“Best Paper Award in the M&Ms-2 Challenge”, by M&Ms2 Challenge organizers and the Medical Image Computing and Computer Assisted Intervention (MICCAI) Society.
Main Project Outcomes
Theses
Ferreira, S. (2021). Cognitive and emotional regulation in stress and obsessive-compulsive disorder. School of Medicine, University of Minho
Papers
Ferreira, S. et al (2019). The efficacy of biofeedback approaches for obsessive-compulsive and related disorders: A systematic review and meta-analysis. Psychiatry Research. https://doi.org/10.1016/j.psychres.2018.12.096
Posters
Ferreira, S., Picó-Pérez, M., Sousa, M., Vieira, R., Morgado, P., Magnetic resonance imaging-based neurofeedback improves obsessive-compulsive symptomatology, ECNP Virtual, 2020
Ferreira, S., Picó-Pérez, M., Sousa, M., Vieira, R., Morgado, P., A feasibility study of fMRI neurofeedback for treatment-resistant obsessive-compulsive disorder, RT-FIN, Maastricht, The Netherlands, 2019.
Scientific outreach:
Dance your PhD contest (School of Medicine, University of Minho) – https://drive.google.com/file/d/1oV4dgrgzNkyz4wshmEaoz1ej0ayyP_zI/view?usp=sharing
Contact us
Phone: +351 253 604 967
Fax: +351 253 604 809
Email: icvs.sec@med.uminho.pt
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
GPS: +41° 33′ 47.33″, -8° 24′ 3.39″
Copyright ©2022 ICVS. All Rights Reserved
Copyright ©2022 ICVS. All Rights Reserved
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
GPS: +41° 33′ 47.33″, -8° 24′ 3.39″
Copyright ©2022 ICVS. All Rights Reserved
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
GPS: +41° 33′ 47.33″, -8° 24′ 3.39″