ICVS

Early life maternal separation induces, in adulthood, anxious and depressive-like behavior and alterations immunological and endocrine parameters

Maternal separation (MS), an early life stressful event, has been demonstrated to trigger neuropsychiatric disorders later in life, in particular depression. However, the mechanism by which MS leads to neuropsychiatric disorders is far from being understood. In the present study, MS was induced in rats in two developmental periods: postnatal days 2–15 (MS2–15) and 7–20 (MS7–20). Behavioral, immunological, and endocrine parameters, frequently associated with depressive-lik ...

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Surgical Sciences researchers awarded at the 45th Annual Meeting of Canadian Association of Paediatric Surgeons

Research conducted by Patrícia P. Terra, Jorge Correia Pinto and collaborators was awarded the Second Prize winner for Podium presentations (oral communications) at the 45th Annual Meeting of Canadian Association of Paediatric Surgeons, Chalottetown, Prince Edward Island. “MicroRNAmiR-200b rescues abnormal branching morphogenesis of nitrofen-inducedhypoplastic lung explants” Patrícia Pereira Terra, Anouk Chantal Deden, Fuqin Zhu, BarbIwasiow, Jorge Correia Pinto, ...

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Researchers from ICVS/3Bs develop a new transgenic mouse model of Machado-Joseph disease and demonstrate a delay of the progression of the disease by 17-DMAG treatment

In a recently published work in Neurotherapeutics, a team of researchers at the Life and Health Sciences Research Institute of the University of Minho led by Prof. Patrícia Maciel and including Anabela Silva-Fernandes and Sara Duarte-Silva describe a new mouse model of Machado-Joseph disease, an inherited neurodegenerative disease caused by mutation in the ATXN3 gene, which until now remains untreatable. This transgenic mouse recapitulates several features of the human disease at the clinical an ...

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A delegation from the Shanghai Institute of Materia Medica visits the University of Minho

A delegation of the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences visited University of Minho and the facilities of the ICVS/3B’s Associate Laboratory. The delegation composed by SIMM directors (Cheng Jianjun and Li Jun) and scientists (Zuo Jianping and Tang Wei) had the opportunity to know more about the research that is performed at ICVS/3B’s, to meet with our scientists and discuss future collaborative projects between the Portuguese and Chinese re ...

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ICVS researchers developed a new behavioral test to assess anhedonia

In a work by António Mateus-Pinheiro, Patrícia Patrício and colleagues, recently published in Frontiers in Behavioral Neuroscience, the ICVS researchers developed a new test to evaluate anhedonic behavior in rodents, called Sweet Drive Test (SDT). Anhedonia is the absence of pleasure from a previously rewarding experience or activity and constitutes a cardinal mark of depression. Studying the neurobiological basis of anhedonia in rodent models is therefore highly relevan ...

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