Advancing current understanding on the clinical impact of HIV-1 subtype C diversity
There is still no cure for HIV infection and the extensive viral genetic diversity represents the one of the biggest obstacles to develop an effective therapy. Our previous results reinforced the importance of understanding the dynamics of HIV-1 subtype expansion and monitoring DRMs prevalence to establish specific guidelines for prevention and treatment in a specific populational group. Within this project, we aim at further investigating the prevalence of DRMs in ART-failing patients in the recent years in prevalent HIV-1 subtypes, to understand the impact of the current changes in treatment guidelines. Overall, this work could provide valuable insights about HIV-1 subtype C genetic diversity and its impact on the HIV-1 infection dynamics.
Main Project Outcomes
S. Queirós, “Right ventricular segmentation in multi-view cardiac MRI using a unified U-net model”, in E. Puyol Antón et al. (eds) Statistical Atlases and Computational Models of the Heart. Multi-Disease, Multi-View, and Multi-Center Right Ventricular Segmentation in Cardiac MRI Challenge. STACOM 2021. Lecture Notes in Computer Science, vol 13131, pp. 287-295, Springer, Cham, 2022.
“Best Paper Award in the M&Ms-2 Challenge”, by M&Ms2 Challenge organizers and the Medical Image Computing and Computer Assisted Intervention (MICCAI) Society.
Main Project Outcomes
Souto, B., Triunfante, V., Santos-Pereira, A., Martins, J., Araújo, P. M. M., & Osório, N. S. (2021). Evolutionary dynamics of HIV-1 subtype C in Brazil. In Scientific Reports (Vol. 11, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1038/s41598-021-02428-3
Santos-Pereira, A., Triunfante, V., Araújo, P. M. M., Martins, J., Soares, H., Poveda, E., Souto, B., & Osório, N. S. (2021). Nationwide Study of Drug Resistance Mutations in HIV-1 Infected Individuals under Antiretroviral Therapy in Brazil. In International Journal of Molecular Sciences (Vol. 22, Issue 10, p. 5304). MDPI AG. https://doi.org/10.3390/ijms22105304
Santos-Pereira, A., Magalhães, C., Araújo, P. M. M., & Osório, N. S. (2021). Evolutionary Genetics of Mycobacterium Tuberculosis and HIV-1: “The Tortoise and the Hare.” In Microorganisms (Vol. 9, Issue 1, p. 147). MDPI AG. https://doi.org/10.3390/microorganisms9010147
Araújo, P. M. M., Carvalho, A., Pingarilho, M., Abecasis, A. B., & Osório, N. S. (2019). Characterization of a large cluster of HIV-1 A1 infections detected in Portugal and connected to several Western European countries. In Scientific Reports (Vol. 9, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1038/s41598-019-43420-2