Exploring SNXs Role in the nervous system: implications for pathology

Our research main focus over the past years has been to understand the molecular mechanisms underlying proteostasis regulation and their relevance for physiological and pathological processes. More specifically, we are interested on understanding how defects in protein homeostasis arising from SNXs’ cargo mis-regulation can negatively affect the nervous and immune systems, particularly during AGING or STRESS exposure. Conditions that trigger endocytic dysregulation and neurological disorders. Ultimately,we aim to validate SNXs as disease-associated biomarkers; to understand the molecular mechanisms involved; and to develop diagnostic/therapeutic tools. These results can potentially contribute to the understanding of aging- and/or stress-associated behavioral impairments and the progression of neurological disorders.

Funding Agency

Internal Funding
Brain and behaviour Research Foundation
FCT

Project Reference

NERD
ID 24929

2022.04850.PTDC

Project Members

Neide Vieira

Assistant Researcher Project Leader

Gisela Armada

PhD Student

Ana Vale

MSc Student

Main Project Outcomes

Gallo, V., ISERC-Team, Gentile, R., Antonini, G. and Iacobelli S. (2022). “Gal-3BP levels in hospitalized patients correlate with COVID-19 severity”. Clinical and Experimental Medicine 25;1-5. DOI: 10.1007/s10238-021-00788-8; IF (2021) – 3,984 (Q2). Neide Vieira is part of the ISERC-Team.

Castro, A. R., Rodrigues, D. R., Castro, M. J., Vieira, N., Vieira, C., Carvalho, A. X., Gassman, R., Abreu, C. M. and Dantas T. J. (2022). “WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing”. Journal of Cell Biology 221 (1): e202010178. DOI: 10.1083/jcb.202010178; IF (2021) – 10,539 (Q1).

Serre-Miranda, C., Roque, S., Barreira-Silva, P., Nóbrega, C., Vieira, N., Costa, P., Palha, J. and Correia-Neves, M. (2021). “Longitudinal evaluation of the peripheral immune system in mice: the moderation effect of sex”. Journal of Gerontology Series A: Biological Sciences and Medical Sciences (2021 Nov 6;glab330). DOI: 10.1093/gerona/glab330; IF (2021) – 6,05 (Q1).

Vieira, N.§, Rito, T., Correia-Neves, M. and Sousa, N. (2021). “Sorting out Sorting nexins role in the nervous system: an evolutionary overview and implications for pathology”. Molecular Neurobiology 58:4070–4106. DOI: 10.1007/s12035-021-02388-9; §Corresponding author: Neide Vieira. IF (2020) – 5,59 (Q1).

Serre-Miranda, C. #, Nóbrega, C.#, Roque, S. #, Canto-Gomes, J., Silva, CS., Vieira, N., Barreira-Silva, P., Alves-Peixoto, P., Cotter, J., Reis, A., Formigo, M., Sarmento, H., Pires, O., Carvalho, A., Petrovykh, D., Diéguez, L., Sousa. JC., Sousa, N., Capela, C., Palha, JA., Cunha, PG. and Correia-Neves, M. (2021). “Performance assessment of 11 commercial serological tests for SARS-CoV-2 on hospitalized COVID-19 patients”. International Journal of Infectious Diseases DOI: 10.1016/j.ijid.2021.01.038; IF (2020) – 3,20 (Q1).

Vieira, N., Bessa, C., Rodrigues, A.J., Marques, P., Chan, FY., Xavier de Carvalho, A., Correia-Neves, M. and Sousa, N (2018). “Caenorhabditis elegans SNX3 mutation leads to impaired development and behavioral deficits”. Cellular and Molecular Life Sciences. 75(11):2027-2044. DOI: 10.1007/s00018-017-2719-2; IF (2018) – 7,04 (Q1).

Aslani, S., Vieira, N., Marques, F., Costa, P., Sousa, N. and Palha, J. (2015) ” The effect of high fat diet on rat’s mood, feeding behavior and response to stress”. Translational Psychiatry. 5:e684. DOI: 10.1038/tp.2015.178 IF (2015) – 5,538 (Q1). Citations: 26. 2 media appearences (Sociedade civil and Mentes que Brilham): November 2016 – Program “Mentes que Brilham” (30/11/2016) -Interview concerning the Brain.
– April 2017 – Program “Sociedade Civil” (10/04/2017) – Invited to discuss the theme: “Trabalhar o Cérebro”. Scientific outreach (brain awarness week activities 2017-2018-2019);