This project aims to unravel the molecular mechanisms behind hemozoin formation in Plasmodium falciparum, a vital process for parasite survival and a key target of antimalarial drugs. Focusing on the role of lipids and their involvement in heme detoxification, we use genetically engineered parasite lines, advanced imaging, and drug susceptibility assays to investigate how disruptions in lipid dynamics affect parasite growth and drug response. Combining expertise in parasitology, molecular biology, and drug resistance, this international collaboration seeks to identify novel targets for antimalarial therapy, contributing to global efforts to improve treatment strategies and overcome drug resistance.