Lipids in Alzheimer’s disease

Here we propose to study how brain regional lipid composition contributes to susceptibility to neurodegenerative disorders. We use different approaches to tackle this question, from mass-spectrometry lipidomic analyses, to manipulation of lipid pathways with genetic and pharmacological models. We are particularly interested in the phospholipase D (PLD) pathway, since we have shown that while ablating the PLD1 isoenzyme leads to brain regional dysfunction, the ablation of PLD2 confers protection in an amyloidogenesis model. We are currently exploring how do these PLD dependent mechanisms confer either resistance or susceptibility to neuronal dysfunction.

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S. Queirós, “Right ventricular segmentation in multi-view cardiac MRI using a unified U-net model”, in E. Puyol Antón et al. (eds) Statistical Atlases and Computational Models of the Heart. Multi-Disease, Multi-View, and Multi-Center Right Ventricular Segmentation in Cardiac MRI Challenge. STACOM 2021. Lecture Notes in Computer Science, vol 13131, pp. 287-295, Springer, Cham, 2022.

“Best Paper Award in the M&Ms-2 Challenge”, by M&Ms2 Challenge organizers and the Medical Image Computing and Computer Assisted Intervention (MICCAI) Society.