Tiago Gil Oliveira

  • lipids
  • hippocampus
  • Alzheimer
  • neurodegeneration
  • MRI

I am currently Associate Professor at the School of Medicine, research line coordinator at ICVS and neuroradiologist at Hospital de Braga. I was a student in the joint MD/PhD program of the University of Minho, Portugal and Columbia University, NYC, USA. I carried out my PhD studies at Columbia University, between 2007 and 2010, and my MD studies at University of Minho. While studying the role of lipid signaling in Alzheimer’s disease pathogenesis, I showed that the ablation of the lipid-modulating enzyme, phospholipase D2, was protective in different Alzheimer’s disease models. Following my MD/PhD, in 2011 I started as an Assistant Professor at the School of Medicine, University of Minho. I have expanded my research interests to the study of mood disorders. Using an unbiased lipidomic approach, my laboratory showed that specific lipid signaling pathways were altered in a chronic stress model, unraveling new potential therapeutic targets. In parallel with my academic work I continued my medical career. I am now using lipidomic approaches together with brain imaging to study neurodegenerative disorders.

Scientific Highlights

Funding – as Principal Investigator
1. 2012 – 2015 – Fundação para a ciência e tecnologia – “The role of brain lipid metabolism in the modulation of chronic stress effects”.

2. 2015 – 2017 – Fundação BIAL – “”The impact of lipid signaling modulation in cognition””.

3. 2019 – 2021 – Fundação BIAL – “The role of interneurons in spatial memory”.

4. 2021 – 2023 – Brain & Behavior Research Foundation, USA – NARSAD Young Investigator Grant – “Studying the differential impact of chronic stress on the longitudinal hippocampal axis by MRI”.

5. 2023 – 2026 – Fundação para a ciência e tecnologia – “The role of phospholipase D2 in Alzheimer’s disease”.

6. 2023 – 2025 – Fundação Amélia de Mello, Bolsa D. Manuel de Mello – “Brain imaging determinants of Alzheimer’s disease neuropathology”.

1. 2022 – Pfizer Award – Clinical Research – Sociedade de Ciências Médicas de Lisboa.

2. 2019 – EMBO Conference Award – Lipid function in Health and Disease, Dresden, Germany.

3. 2017 – “2017 ICVS Research Award”.

1. 2019 – present – Vice-President of the Portuguese Society for Neuroscience (SPN).


Lipids in Alzheimer’s disease

Here we propose to study how brain regional lipid composition contributes to susceptibility to neurodegenerative disorders. We use different approaches to tackle this question, from mass…

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